CDCA5与卵巢癌关系的研究进展

Research Progress on the Relationship between CDCA5 and Ovarian Cancer

摘要: 正常细胞周期的丧失会导致恶性肿瘤的发展。癌细胞的一个标志性特征是它们能够逃避细胞周期检查点，导致不受控制的增殖和肿瘤生长。细胞分裂周期相关蛋白(Cell Division Cycle-Associated Protein, CDCA)家族包括CDCA2、CDCA3、CDCA4、CDCA5、CDCA7和CDCA8，它们是一类参与细胞周期调控、有丝分裂和染色体稳定性的基因，在各种细胞过程中发挥重要作用，是调节细胞周期进程的关键调节因子，共同参与促进了细胞分裂和基因组稳定性。近期，细胞分裂周期相关5 (CDCA5)在癌症研究中获得越来越多的关注。有研究已经证实，在多种恶性肿瘤中都存在CDCA5的高表达。近几年来，CDCA5与卵巢癌的关系也陆续受到广泛关注，本文旨在系统综述CDCA5在卵巢癌中的研究进展，分析其表达特征、临床相关性及治疗潜力，以期为卵巢癌的诊断及治疗提供理论依据。

Abstract: The loss of the normal cell cycle can lead to the development of malignant tumors. One characteristic of cancer cells is their ability to evade cell cycle checkpoints, leading to uncontrolled proliferation and tumor growth. The cell division cycle-associated protein (CDCA) family includes CDCA2, CDCA3, CDCA4, CDCA5, CDCA7 and CDCA8. They are genes involved in cell cycle regulation, mitosis and chromosomal stability, playing a significant role in various cellular processes. They are key regulatory factors in regulating the progress of the cell cycle and jointly participate in promoting cell division and genomic stability. Recently, cell division cycle-related 5 (CDCA5) has received increasing attention in cancer research. Studies have confirmed that CDCA5 is highly expressed in various malignant tumors, such as melanoma, gastric cancer, bladder cancer, and breast cancer. In recent years, the relationship between CDCA5 and ovarian cancer has received extensive attention. This article aims to systematically review the research progress of CDCA5 in ovarian cancer, analyze its expression characteristics, clinical relevance and therapeutic potential, with the expectation of providing a theoretical basis for the diagnosis and treatment of ovarian cancer.