肿瘤微环境过氧化氢探针的研究进展
Research Progress on Hydrogen Peroxide Probes in the Tumor Microenvironment
DOI: 10.12677/acm.2025.15113365, PDF,    科研立项经费支持
作者: 王心悦, 宋雨晨, 钱 研, 郭兰英*：皖南医学院医学影像学院，安徽 芜湖
关键词: 过氧化氢探针；肿瘤微环境；生物成像；Hydrogen Peroxide Probe； Tumor Microenvironment； Bioimaging
摘要: 过氧化氢(H2O2)作为肿瘤微环境的关键调控分子，其异常表达与肿瘤发生发展密切相关。近年来，针对肿瘤H2O2检测的分子探针技术取得了突破性进展。本文综述了2022~2025年间肿瘤H2O2探针的研究现状，重点介绍了硼酸盐类探针、无酶电化学传感器以及化学发光法传感器等新型检测技术的设计原理和性能特点。本文分析了当前技术面临的挑战，并对未来发展方向进行了展望，为肿瘤早期诊断、术中导航和治疗监测提供新思路。
Abstract: As a pivotal regulatory molecule within the tumor microenvironment (TME), hydrogen peroxide (H2O2) exhibits aberrant expression levels that are closely associated with tumorigenesis and progression. In recent years, molecular probe technologies targeting H2O2 detection in tumors have witnessed groundbreaking advances. This review comprehensively summarizes the research progress on H2O2-specific probes from 2022 to 2025, with a dedicated focus on the design principles and performance characteristics of emerging detection modalities, including boronate-based probes, enzyme-free electrochemical sensors, and advanced fluorescent probes. Furthermore, it critically analyzes the current technical challenges and outlines future research directions, aiming to provide novel insights for early cancer diagnosis, intraoperative navigation, and treatment response monitoring.
文章引用：王心悦, 宋雨晨, 钱研, 郭兰英. 肿瘤微环境过氧化氢探针的研究进展[J]. 临床医学进展, 2025, 15(11): 2416-2423. https://doi.org/10.12677/acm.2025.15113365

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