肌肉因子与慢性肾脏病的研究进展

Research Progress on Myokines and Chronic Kidney Disease

摘要: 慢性肾脏病(CKD)已成为全球范围内的重大公共卫生问题，其患病率持续上升。CKD患者往往伴有多种并发症，这极大地影响了他们的生活质量，并增加了死亡风险。近期的科学研究强调了肌肉因子在调节各种生理过程中的关键作用。值得注意的是，一些关键肌细胞因子与肾功能恶化存在潜在关联，这提示需要对其病理生理作用进行更深入的研究。本篇文章以慢性肾脏病为本体对象，旨在探究三种关键的肌肉因子——MSTN、irisin和adropin与慢性肾脏病发病机制之间的相互作用，以及它们与慢性肾脏病进展之间的关联，并探讨了由肌肉因子介导的肌肉–肾脏相互作用的研究进展。

Abstract: Chronic kidney disease (CKD) has become a major public health issue worldwide, with its prevalence continuing to rise. CKD patients often suffer from multiple complications, which significantly affect their quality of life and increase the risk of death. Recent scientific research has emphasized the crucial role of myokines in regulating various physiological processes. It is notable that some key myokines are potentially associated with deterioration of renal function, suggesting the need for more in-depth studies on their pathophysiological effects. This article focuses on chronic kidney disease as the main subject, aiming to explore the interactions between three key myokines—MSTN, irisin, and adropin—and the pathogenesis of chronic kidney disease, as well as their associations with the progression of chronic kidney disease, and discusses the research progress of muscle-kidney interactions mediated by myokines.