针刺联合疗法治疗格林–巴利综合征的研究进展

Research Advances in Acupuncture Combination Therapy for Guillain-Barré Syndrome

摘要: 格林–巴利综合征(GBS)是一种自身免疫介导的急性周围神经病，目前西医主要采用血浆置换和静脉注射免疫球蛋白的治疗方法，但存在副作用明显及价格高昂等问题。近年来，针刺联合电针、康复训练、中药、推拿、穴位注射、穴位埋线及蜡疗等多种方法在治疗本病中展现出较好疗效，这种联合疗法可有效提高患者免疫功能、减轻炎症反应、改善神经功能、促进运动功能恢复、从而降低致残率及并发症发生率且安全经济。本文通过总结近年来的相关文献，探讨针刺联合疗法在本病治疗中的现状及存在的问题，旨在为临床实践提供参考，为未来研究治疗本病提供新思路。

Abstract: Guillain-Barré syndrome (GBS) is an autoimmune-mediated acute peripheral neuropathy. Current conventional medical interventions predominantly utilize plasmapheresis and intravenous immunoglobulin administration, which are associated with significant adverse effects and substantial financial burdens. In recent years, integrated therapeutic approaches combining acupuncture with electrostimulation, neuromotor rehabilitation, phytopharmaceuticals, manual therapy, acupoint pharmacological interventions, acupoint catgut embedding, and thermotherapeutic wax applications have demonstrated promising clinical outcomes. This combinatorial treatment modality exhibits multifaceted therapeutic benefits including immunoregulatory effects, anti-inflammatory actions, neural functional enhancement, and motor recovery facilitation, thereby reducing disability rates and complication incidence while demonstrating favorable cost-effectiveness and safety profiles. This comprehensive review synthesizes recent evidence to elucidate the current status and persisting challenges of acupuncture-based combinatorial therapies in GBS management. The analysis aims to provide evidence-based references for clinical decision-making and propose novel investigative directions for optimizing therapeutic strategies in this debilitating neurological disorder.