芳烃的脱芳构化双官能团化反应研究
Research on the Dearomatization and Bifunctionalization Reaction of Aromatic Hydrocarbons
DOI: 10.12677/jocr.2025.134034, PDF,   
作者: 梁国庆：浙江师范大学，化学与材料科学学院，浙江 金华
关键词: 脱芳构化；双官能团化；芳香环；Dearomatization； Bifunctionalization； Aromatic Ring
摘要: 芳烃的脱芳构化双官能团化反应作为有机合成领域的重要研究方向之一，因其能够将稳定的芳香环结构转化为具有丰富反应活性的多官能团化的脂肪族化合物，在天然产物合成、药物化学及材料科学等领域展现出巨大应用潜力。芳香环因共轭大π键的存在而具备特殊稳定性，其脱芳构化过程需打破共轭体系，同时引入两种不同官能团，这一过程既需要精准控制反应的区域选择性和化学选择性，又需解决反应活性与选择性之间的平衡问题。本文综述过渡金属催化剂，光催化，以及重排加成等方法成功实现了多种芳烃的脱芳构化双官能团化转化的进展。
Abstract: The dearomatization and bifunctionalization of aromatic hydrocarbons, as one of the important research directions in organic synthesis, has shown great application potential in the fields of natural product synthesis, medicinal chemistry, and materials science due to its ability to convert stable aromatic ring structures into multifunctionalized aliphatic compounds with rich reactivity. The aromatic ring has special stability due to the existence of a conjugated large π bond, and its dearomatization process requires breaking the conjugated system and simultaneously introducing two different functional groups. This process not only needs precise control of the regioselectivity and chemoselectivity of the reaction, but also needs to solve the balance problem between reactivity and selectivity. This article reviews the progress of various methods, including transition metal catalysts, photocatalysis, and rearrangement addition, in successfully achieving the dearomatization and bifunctionalization transformation of various aromatic hydrocarbons.
文章引用：梁国庆. 芳烃的脱芳构化双官能团化反应研究[J]. 有机化学研究, 2025, 13(4): 348-357. https://doi.org/10.12677/jocr.2025.134034

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