长链非编码RNA NEAT1在肝细胞癌中的研究进展
Research Progress on the Long Non-Coding RNA NEAT1 in Hepatocellular Carcinoma
DOI: 10.12677/acm.2025.15123451, PDF,   
作者: 尹 杰：北华大学附属医院普外科，吉林 吉林；李彦冬*：北华大学附属医院感染科，吉林 吉林
关键词: 长链非编码RNA；NEAT1；肝细胞癌；分子机制；治疗靶点；Long Non-Coding RNA； NEAT1； Hepatocellular Carcinoma； Molecular Mechanisms； Therapeutic Target
摘要: 肝细胞癌(HCC)是一种在全球发病率与致死率都不低的恶性肿瘤，给人类健康带来了极大威胁，长链非编码RNA (lncRNA)缘于在肿瘤发生与发展时扮演着关键调控角色，已经变成肿瘤生物学研究的一个核心焦点，NEAT1作为一种在细胞核中表达水平很高的lncRNA，其在肝细胞癌中的异常表达情况和相关分子机制逐渐被揭示，表明其在肿瘤细胞的增殖、迁移以及抵抗药物能力方面起关键作用。现阶段对NEAT1功能的认知尚显不足，其相关机制还未得到全面阐释，本文系统地总结回顾了NEAT1在肝细胞癌中的表达特征、调控网络及其临床应用潜在能力，着重分析了其作为诊断标志物和治疗靶点的应用潜力前景，目的在于推动肝细胞癌精准诊疗策略的研发及优化。
Abstract: Hepatocellular carcinoma (HCC) is a malignant tumor with significant global incidence and mortality rates, posing a major threat to human health. Long non-coding RNAs (lncRNAs), due to their pivotal regulatory roles in tumorigenesis and progression, have become a central focus in tumor biology research. NEAT1, a highly expressed lncRNA in the cell nucleus, has been increasingly implicated in HCC through its abnormal expression patterns and associated molecular mechanisms. Evidence suggests it plays a pivotal role in tumor cell proliferation, migration, and drug resistance. Current understanding of NEAT1’s functions remains incomplete, and its underlying mechanisms have not been fully elucidated. This review systematically summarizes NEAT1’s expression patterns, regulatory networks, and potential clinical applications in hepatocellular carcinoma, with a particular emphasis on its prospects as a diagnostic biomarker and therapeutic target. The aim is to advance the development and optimization of precision diagnostic and therapeutic strategies for hepatocellular carcinoma.
文章引用：尹杰, 李彦冬. 长链非编码RNA NEAT1在肝细胞癌中的研究进展[J]. 临床医学进展, 2025, 15(12): 620-628. https://doi.org/10.12677/acm.2025.15123451

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