口腔鳞癌免疫代谢重编程：从机制到临床转化
Immune Metabolic Reprogramming in Oral Squamous Cell Carcinoma: From Mechanisms to Clinical Translation
摘要: 在口腔鳞状细胞癌中，代谢特征与免疫反应间相互影响，免疫代谢在细胞增殖、分化和功能反应中起着关键作用。肿瘤微环境(TME)对免疫细胞的正常功能施加了多重障碍，包括代谢挑战和免疫抑制微环境。同时肿瘤细胞代谢活性的增强会导致免疫细胞所需关键营养物质的消耗或通过代谢物或信号通路调节免疫细胞功能，从而促进口腔鳞状细胞癌进展或免疫逃避。因此，靶向代谢网络来重编程免疫细胞表型并增强抗肿瘤免疫力，对于临床转化具有重要的前景。本综述重点探讨了OSCC肿瘤微环境中葡萄糖、氨基酸和脂质代谢改变对免疫细胞代谢和功能的影响以及总结了各种免疫细胞亚群特有的代谢重编程。最后，探讨了靶向代谢检查点的潜在策略，旨在为开发新型免疫疗法提供新的思路。
Abstract: In oral squamous cell carcinoma, metabolic characteristics and immune responses interact reciprocally, with immunometabolism playing a pivotal role in cellular proliferation, differentiation, and functional responses. The tumor microenvironment (TME) imposes multiple barriers to normal immune cell function, including metabolic challenges and an immunosuppressive microenvironment. Concurrently, enhanced metabolic activity in tumor cells depletes key nutrients required by immune cells or modulates immune cell function via metabolites or signaling pathways, thereby promoting oral squamous cell carcinoma progression or immune evasion. Consequently, targeting metabolic networks to reprogram immune cell phenotypes and enhance antitumor immunity holds significant promise for clinical translation. This review focuses on examining the impact of altered glucose, amino acid, and lipid metabolism in the OSCC tumor microenvironment on immune cell metabolism and function, while summarizing metabolism-specific reprogramming across various immune cell subsets. Finally, potential strategies targeting metabolic checkpoints are explored to provide novel insights for developing novel immunotherapies.
文章引用：李文昕, 鲁文轩, 杨凯. 口腔鳞癌免疫代谢重编程：从机制到临床转化[J]. 临床医学进展, 2025, 15(12): 629-638. https://doi.org/10.12677/acm.2025.15123452

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