常见化疗药物诱导口周神经病变的相关探讨
Related Discussion on Common Chemotherapy Drugs Inducing Perioral Neuropathy
摘要: 化疗诱导的周围神经病变(CIPN)作为细胞毒性化疗药物的常见并发症，其影响范围广泛，包括口腔及口周区域，这一现象虽报道较少，但不容忽视。本综述旨在系统梳理并分析排除由头颈部肿瘤、放疗、口咽黏膜炎、感染或术后疼痛等直接引起的口腔及口周化疗诱发周围神经病变(OCIPN)的相关数据，细胞毒性化疗药物在此区域神经毒性作用，包括颌骨疼痛或麻木。通过检索PubMed和Cochrane数据库至2025年6月，并遵循严格的文献筛选标准，我们汇总了铂类、紫杉烷类、长春花生物碱、免疫调节剂及烷基化剂等药物在OCIPN方面的表现，为临床医生提供有价值的参考。
Abstract: Chemotherapy-induced peripheral neuropathy (CIPN) is a frequent complication of cytotoxic chemotherapeutic agents; its incidence largely varies, depending on type, dose, agent and preexisting risk factors. Oral-and-peri-oral-CIPN (OCIPN) is underreported. A narrative literature review, following SANRA guidelines was conducted. PubMed and Cochrane databases were searched until now. Articles referring to neuropathy or neuropathic pain due to head and neck cancer, head and neck radiotherapy, oropharyngeal mucositis, infection or post-surgical pain were excluded. Platinum-based chemotherapeutics, taxanes, vinca alkaloids, immunomodulatory and alkylating agents can cause OCIPN.
文章引用：李婉茹, 陈军. 常见化疗药物诱导口周神经病变的相关探讨[J]. 临床医学进展, 2025, 15(12): 738-745. https://doi.org/10.12677/acm.2025.15123465

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