Wnt/β-Catenin信号通路调控成骨细胞分化的机制及靶向该通路抗骨质疏松天然化合物研究进展
Research Progress on the Mechanism of Wnt/β-Catenin Signaling Pathway Regulating Osteoblast Differentiation and Natural Compounds Targeting This Pathway against Osteoporosis
摘要: 成骨细胞作为骨骼形成与重塑过程中的核心功能细胞，其主要起源于骨髓间充质干细胞。这些干细胞经定向分化生成成骨细胞后，可通过分泌骨基质、调控骨形成过程及参与骨组织重塑等关键生物学功能，维持骨骼系统的结构完整与代谢平衡。骨细胞功能异常或分化障碍会直接诱发多种骨骼相关疾病，其中骨质疏松症、骨折愈合延迟及骨骼畸形等临床常见病症，已成为影响人群健康的重要问题。近年来，随着对PTH类药物、生物磷酸盐类药物、钙调素类药物应用所引起的副作用，人们对成骨细胞分化机制进行了更深入的研究，并积极寻找天然化合物对骨质疏松的治疗方法。Wnt/β-catenin信号通路被认为是成骨细胞分化的重要通路之一，已经成为治疗骨质疏松症的重要靶点。本文将对Wnt/β-catenin信号通路对成骨细胞分化的影响做简要概述，并系统总结近年来靶向该通路的抗骨质疏松天然化合物的最新研究进展，为相关疾病的临床治疗及天然药物研发提供参考。
Abstract: As the core functional cells in the process of bone formation and remodeling, osteoblasts are mainly derived from bone marrow mesenchymal stem cells. These stem cells can maintain the structural integrity and metabolic balance of the skeletal system by secreting bone matrix, regulating the process of bone formation and participating in bone tissue remodeling. Abnormal or abnormal differentiation of bone cells can directly induce a variety of bone-related diseases, including osteoporosis, delayed fracture healing and skeletal deformities, which have become important problems affecting human health. In recent years, with the side effects caused by the application of PTH drugs, biphosphonate drugs, and calmodulin drugs, people have carried out more in-depth research on the mechanism of osteoblast differentiation, and are actively looking for natural compounds for the treatment of osteoporosis. The Wnt/β-catenin signaling pathway is considered to be one of the important pathways of osteoblast differentiation and has become an important target for the treatment of osteoporosis. In this review, we briefly summarize the effect of the Wnt/β-catenin signaling pathway on osteoblast differentiation, and systematically summarize the latest research progress of natural anti-osteoporosis compounds targeting this pathway in recent years, so as to provide a reference for the clinical treatment of related diseases and the development of natural drugs.
文章引用：王晓浩, 陈森. Wnt/β-Catenin信号通路调控成骨细胞分化的机制及靶向该通路抗骨质疏松天然化合物研究进展[J]. 临床医学进展, 2025, 15(12): 793-802. https://doi.org/10.12677/acm.2025.15123472

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