免疫营养成分及其在头颈癌患者管理中的应用
Immunonutrient Components and Their Application in the Management of Head and Neck Cancer Patients
DOI: 10.12677/acm.2025.15123500, PDF,    科研立项经费支持
作者: 吝鑫华*, 秦涵彬：山东第二医科大学临床医学院，山东 潍坊；青岛大学附属烟台毓璜顶医院耳鼻咽喉头颈外科，山东 烟台；山东省耳鼻喉疾病临床医学研究中心，山东 烟台；烟台市耳鼻喉疾病重点实验室，山东 烟台；郭文涛*, 柳忠禄, 张 强, 张 华#：青岛大学附属烟台毓璜顶医院耳鼻咽喉头颈外科，山东 烟台；山东省耳鼻喉疾病临床医学研究中心，山东 烟台；烟台市耳鼻喉疾病重点实验室，山东 烟台；吕晓静, 隋嘉辛：青岛大学附属烟台毓璜顶医院耳鼻咽喉头颈外科，山东 烟台；山东省耳鼻喉疾病临床医学研究中心，山东 烟台；烟台市耳鼻喉疾病重点实验室，山东 烟台；青岛大学青岛医学院，山东 青岛；张子乐：青岛大学附属烟台毓璜顶医院耳鼻咽喉头颈外科，山东 烟台；山东省耳鼻喉疾病临床医学研究中心，山东 烟台；烟台市耳鼻喉疾病重点实验室，山东 烟台；滨州医学院第二临床医学院，山东 烟台；刘雪霞：青岛大学附属烟台毓璜顶医院中心实验室，山东省干细胞工程技术研究中心，山东 烟台
关键词: 头颈部肿瘤；免疫营养；精氨酸；谷氨酰胺；ω-3多不饱和脂肪酸；Head and Neck Tumors； Immune Nutrition； Arginine； Glutamine； Omega-3 Polyunsaturated Fatty Acids
摘要: 头颈癌(HNC)涵盖口腔、咽、喉、鼻腔等多区域肿瘤，是全球第七大常见癌症。受疾病本身及治疗等因素影响，HNC患者常出现营养状况受损与免疫功能障碍，典型表现为吞咽困难、体重下降等恶病质症状。临床中，常规饮食难以满足患者因肿瘤消耗增加的营养需求，因此免疫营养(IN)在癌症治疗中的作用日益凸显。目的：本文旨在总结近年来IN对HNC患者影响的最新证据。方法：通过梳理近15年相关文献，分析IN在该群体中的应用效果。结果：研究结果显示，IN可在不同程度上调节免疫细胞不同亚群的反应性，同时积极促进协同抗肿瘤作用，对改善患者生活质量具有积极意义，为HNC患者的营养支持与治疗提供了重要参考方向。
Abstract: Head and neck cancer (HNC) covers multiple regional tumors, such as oral cavity, pharynx, larynx and nasal cavity, and is the seventh most common cancer in the world. Affected by the disease itself and treatment and other factors, HNC patients often suffer from impaired nutritional status and immune dysfunction, typically manifested as cachexia symptoms such as dysphagia and weight loss. In clinic, conventional diet is difficult to meet the nutritional needs of patients due to increased tumor consumption, so the role of immunonutrition (IN) in cancer treatment is increasingly prominent. Objective: This article aims to summarize the latest evidence on the impact of IN on HNC patients in recent years. Methods: By combing the relevant literature in the past 15 years, the application effect of IN in this group was analyzed. Results: The results showed that IN could regulate the reactivity of different subsets of immune cells to different degrees, and actively promote the synergistic anti-tumor effect, which was of positive significance to improve the quality of life of patients, and provided an important reference direction for the nutritional support and treatment of HNC patients.
文章引用：吝鑫华, 郭文涛, 吕晓静, 秦涵彬, 隋嘉辛, 张子乐, 柳忠禄, 张强, 刘雪霞, 张华. 免疫营养成分及其在头颈癌患者管理中的应用[J]. 临床医学进展, 2025, 15(12): 1031-1041. https://doi.org/10.12677/acm.2025.15123500

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