血清硒蛋白P参与儿童中枢性性早熟发病机制的研究进展
Research Progress on the Involvement of Selenoprotein P in the Pathogenesis of Central Precocious Puberty in Children
摘要: 儿童中枢性性早熟(Central Precocious Puberty, CPP)是儿科内分泌领域的常见疾病，其发病机制复杂，涉及神经内分泌调节、遗传、环境等多方面因素。近年来，血清硒蛋白P (Selenoprotein P, SeP)在CPP发病中的作用逐渐受到关注。本文综述了血清硒蛋白P的结构与功能，以及其在儿童中枢性性早熟发病机制中的研究现状，包括血清硒蛋白P对下丘脑–垂体–性腺轴(Hypothalamic-Pituitary-Gonadal Axis, HPGA)的调控作用、与胰岛素样生长因子-1 (Insulin-like Growth Factor-1, IGF-1)等相关因子的相互作用，同时探讨了当前研究存在的不足及未来研究方向，旨在为儿童中枢性性早熟的病因研究和临床防治提供新的思路。
Abstract: Central Precocious Puberty (CPP) is a common disease in the field of pediatric endocrinology. Its pathogenesis is complex, involving multiple factors such as neuroendocrine regulation, genetics, and the environment. In recent years, the role of Selenoprotein P (SeP) in the pathogenesis of CPP has gradually attracted attention. This article reviews the structure and function of SeP, as well as the current research status of its involvement in the pathogenesis of CPP in children—including the regulatory effect of SeP on the Hypothalamic-Pituitary-Gonadal Axis (HPGA) and its interaction with related factors such as Insulin-like Growth Factor-1 (IGF-1). Meanwhile, it discusses the limitations of current research and future research directions, aiming to provide new insights for the etiological research, clinical prevention, and treatment of CPP in children.
文章引用：王妍, 黄伟. 血清硒蛋白P参与儿童中枢性性早熟发病机制的研究进展[J]. 临床医学进展, 2025, 15(12): 1111-1117. https://doi.org/10.12677/acm.2025.15123510

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