类风湿关节炎合并肺间质疾病研究进展
Research Progress on Rheumatoid Arthritis Complicated with Interstitial Lung Disease
DOI: 10.12677/acm.2025.15123533, PDF,   
作者: 吴博婧*:齐齐哈尔市第一医院风湿免疫一科,黑龙江 齐齐哈尔;刘荣清:宁夏医科大学总医院风湿免疫科,宁夏 银川
关键词: 类风湿关节炎肺间质疾病机制诊断治疗Rheumatoid Arthritis Pulmonary Interstitial Disease Mechanism Diagnosis Treatment
摘要: RA是一种以累及小关节为主的对称性、破坏性慢性自身免疫性疾病,累及关节、肺脏、心肌等多器官损害,肺间质病变是肺部受累最常见的。RA的病理学机制是滑膜液中的炎症细胞、滑膜细胞在细胞因子的介导下在关节软骨表面堆积形成血管翳。血管翳会导致软骨和骨的破坏,最终导致关节破环,甚至出现关节畸形。
Abstract: Rheumatoid arthritis (RA) is a symmetrical and destructive chronic autoimmune disease mainly involving small joints, with damage to multiple organs such as joints, lungs, and heart muscles. Pulmonary interstitial disease is the most common manifestation of lung involvement. The pathological mechanism of RA is that inflammatory cells and synovial cells in the synovial fluid accumulate on the surface of articular cartilage to form pannus under the mediation of cytokines. Pannus leads to the destruction of cartilage and bone, ultimately resulting in joint destruction and even joint deformity.
文章引用:吴博婧, 刘荣清. 类风湿关节炎合并肺间质疾病研究进展[J]. 临床医学进展, 2025, 15(12): 1316-1324. https://doi.org/10.12677/acm.2025.15123533

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