慢性腰痛患者25羟基维生素D浓度及其与睡眠质量和临床症状的相关性研究

A Study on Serum 25-Hydroxyvitamin D Concentration and Its Correlation with Sleep Quality and Clinical Symptoms in Patients with Chronic Low Back Pain

摘要: 目的：探讨慢性腰痛(chronic low back pain, CLBP)患者血清25羟基维生素D3 (25(OH)D)浓度及其与睡眠质量和临床症状的相关性。方法：选择2023年12月~2025年6月在我科就诊的64例CLBP患者作为CLBP组，按照1:1的比例抽取同期健康受试者64例作为对照。采用Spearman相关分析验证血清25(OH)D与睡眠质量及VAS评分、ODI指数的相关性。结果：CLBP组血清25(OH)D浓度显著低于对照组，差异有统计学意义(P < 0.05)。Spearman相关性分析显示，CLBP患者血清25(OH)D水平与VAS评分(r = −0.629, P < 0.01)、ODI指数(r = −0.541, P < 0.01)、PSQI (r = −0.456, P < 0.01)均呈负相关。结论：CLBP患者血清25(OH)D浓度与睡眠质量和临床症状存在相关性。这对于CLBP的防治具有重要的临床意义。然而，由于样本量较小，未来还需要进一步的大规模研究来验证这些发现。

Abstract: Objective: To investigate the serum 25-hydroxyvitamin D3 (25(OH)D) concentration in patients with chronic low back pain (CLBP) and its correlation with sleep quality and clinical symptoms. Methods: A total of 64 CLBP patients treated in our department from December 2023 to June 2025 were selected as the CLBP group. According to a 1:1 ratio, 64 healthy subjects during the same period were recruited as the control group. Spearman correlation analysis was used to examine the correlations between serum 25(OH)D levels and sleep quality, VAS scores, and ODI index. Results: The serum 25(OH)D concentration in the CLBP group was significantly lower than that in the control group, and the difference was statistically significant (P < 0.05). Spearman correlation analysis revealed that serum 25(OH)D levels in CLBP patients were negatively correlated with VAS scores (r = −0.629, P < 0.01), ODI index (r = −0.541, P < 0.01), and PSQI scores (r = −0.456, P < 0.01). Conclusion: The serum 25(OH)D concentration in CLBP patients is correlated with sleep quality and clinical symptoms. This finding holds significant clinical implications for the prevention and treatment of CLBP. However, due to the small sample size, further large-scale studies are needed to validate these findings.