经腹联合经阴道超声诊断卵巢中肾样腺癌1例并临床病理特征分析
Transabdominal Combined with Transvaginal Ultrasound in the Diagnosis of Ovarian Mesonephric-Like Adenocarcinoma: One Case Report and Analysis of Clinicopathological Features and Imaging Findings
DOI: 10.12677/md.2025.156081, PDF,   
作者: 迟百源*, 黄佳瑜, 刘唐影：西北民族大学医学部，甘肃 兰州；孙 阳：中国人民解放军联勤保障部队第940医院生殖医学中心，甘肃 兰州；孙厚坦#：中国人民解放军联勤保障部队第940医院超声诊断科，甘肃 兰州
关键词: 超声检查；卵巢；输卵管；卵巢肿瘤；中肾样腺癌；Ultrasonography； Ovary； Fallopian Tube； Ovarian Neoplasm； Mesonephric-Like Adenocarcinoma
摘要: 中肾样腺癌(Mesonephric-like Adenocarcinoma)有研究表明其可能来源于苗勒管上皮，然后沿中肾途径分化，发生于卵巢中肾样腺癌罕见且诊断困难，无特异性临床表现。本文报道了联勤保障部队第940医院1例经病理证实的卵巢中肾样腺癌患者，通过病例报道并分析其临床资料、组织学特征、免疫表型、影像学表现并复习相关文献，以提高医务人员对该肿瘤的认识，为临床实践提供参考。
Abstract: Mesonephric-like adenocarcinoma (MLA) is thought to potentially originate from the Müllerian epithelium, subsequently differentiating along mesonephric pathways. Ovarian MLA is rare and diagnostically challenging, with no specific clinical manifestations. This article reports a case of ovarian MLA confirmed by pathology at the 940th Hospital of the Joint Logistics Support Force. Through this case report, we analyze the clinical data, histological features, immunophenotype, and imaging findings, and review relevant literature to enhance medical professionals’ understanding of this tumor and provide reference for clinical practice.
文章引用：迟百源, 孙阳, 黄佳瑜, 刘唐影, 孙厚坦. 经腹联合经阴道超声诊断卵巢中肾样腺癌1例并临床病理特征分析[J]. 医学诊断, 2025, 15(6): 600-605. https://doi.org/10.12677/md.2025.156081

参考文献

[1] Cree, I.A., White, V.A., Indave, B.I. and Lokuhetty, D. (2019) Revising the WHO Classification: Female Genital Tract Tumours. Histopathology, 76, 151-156. [Google Scholar] [CrossRef] [PubMed]
[2] Mirkovic, J., McFarland, M., Garcia, E., Sholl, L.M., Lindeman, N., MacConaill, L., et al. (2018) Targeted Genomic Profiling Reveals Recurrent KRAS Mutations in Mesonephric-Like Adenocarcinomas of the Female Genital Tract. American Journal of Surgical Pathology, 42, 227-233. [Google Scholar] [CrossRef] [PubMed]
[3] da Silva, E.M., Fix, D.J., Sebastiao, A.P.M., Selenica, P., Ferrando, L., Kim, S.H., et al. (2021) Mesonephric and Mesonephric-Like Carcinomas of the Female Genital Tract: Molecular Characterization Including Cases with Mixed Histology and Matched Metastases. Modern Pathology, 34, 1570-1587. [Google Scholar] [CrossRef] [PubMed]
[4] Chapel, D.B., Joseph, N.M., Krausz, T. and Lastra, R.R. (2018) An Ovarian Adenocarcinoma with Combined Low-Grade Serous and Mesonephric Morphologies Suggests a Müllerian Origin for Some Mesonephric Carcinomas. International Journal of Gynecological Pathology, 37, 448-459. [Google Scholar] [CrossRef] [PubMed]
[5] Pors, J., Cheng, A., Leo, J.M., Kinloch, M.A., Gilks, B. and Hoang, L. (2018) A Comparison of GATA3, TTF1, CD10, and Calretinin in Identifying Mesonephric and Mesonephric-Like Carcinomas of the Gynecologic Tract. American Journal of Surgical Pathology, 42, 1596-1606. [Google Scholar] [CrossRef] [PubMed]
[6] Kenny, S.L., McBride, H.A., Jamison, J. and McCluggage, W.G. (2012) Mesonephric Adenocarcinomas of the Uterine Cervix and Corpus: HPV-Negative Neoplasms That Are Commonly PAX8, CA125, and HMGA2 Positive and That May Be Immunoreactive with TTF1 and Hepatocyte Nuclear Factor 1-β. American Journal of Surgical Pathology, 36, 799-807. [Google Scholar] [CrossRef] [PubMed]
[7] Lin, D.I., Shah, N., Tse, J.Y., Killian, J.K., Hemmerich, A., Edgerly, C., et al. (2020) Molecular Profiling of Mesonephric and Mesonephric-Like Carcinomas of Cervical, Endometrial and Ovarian Origin. Gynecologic Oncology Reports, 34, Article ID: 100652. [Google Scholar] [CrossRef] [PubMed]
[8] Dundr, P., Gregová, M., Němejcová, K., Bártů, M., Hájková, N., Hojný, J., et al. (2020) Ovarian Mesonephric-Like Adenocarcinoma Arising in Serous Borderline Tumor: A Case Report with Complex Morphological and Molecular Analysis. Diagnostic Pathology, 15, Article No. 91. [Google Scholar] [CrossRef] [PubMed]
[9] Pors, J., Segura, S., Chiu, D.S., Almadani, N., Ren, H., Fix, D.J., et al. (2020) Clinicopathologic Characteristics of Mesonephric Adenocarcinomas and Mesonephric-Like Adenocarcinomas in the Gynecologic Tract. American Journal of Surgical Pathology, 45, 498-506. [Google Scholar] [CrossRef] [PubMed]
[10] Sugitani, A., Ogawa, A., Yoshida, H., Kobayashi-Kato, M., Kikkawa, N., Tanase, Y., et al. (2023) Ovarian Mesonephric-Like Adenocarcinoma with Recurrent Liver Metastases: A Case Report with Analysis of Therapeutic Molecular Targets. International Journal of Surgical Pathology, 32, 578-585. [Google Scholar] [CrossRef] [PubMed]
[11] Deolet, E., Arora, I., Van Dorpe, J., Van der Meulen, J., Desai, S., Van Roy, N., et al. (2021) Extrauterine Mesonephric-Like Neoplasms. American Journal of Surgical Pathology, 46, 124-133. [Google Scholar] [CrossRef] [PubMed]
[12] McFarland, M., Quick, C.M. and McCluggage, W.G. (2016) Hormone Receptor‐Negative, Thyroid Transcription Factor 1‐positive Uterine and Ovarian Adenocarcinomas: Report of a Series of Mesonephric‐Like Adenocarcinomas. Histopathology, 68, 1013-1020. [Google Scholar] [CrossRef] [PubMed]
[13] Kolin, D.L., Costigan, D.C., Dong, F., Nucci, M.R. and Howitt, B.E. (2019) A Combined Morphologic and Molecular Approach to Retrospectively Identify Kras-Mutated Mesonephric-Like Adenocarcinomas of the Endometrium. American Journal of Surgical Pathology, 43, 389-398. [Google Scholar] [CrossRef] [PubMed]
[14] Euscher, E.D., Bassett, R., Duose, D.Y., Lan, C., Wistuba, I., Ramondetta, L., et al. (2019) Mesonephric-Like Carcinoma of the Endometrium: A Subset of Endometrial Carcinoma with an Aggressive Behavior. American Journal of Surgical Pathology, 44, 429-443. [Google Scholar] [CrossRef] [PubMed]