Michael加成反应在合成中的应用策略研究
Research on Strategies for Applications of Michael Addition Reaction in Synthesis
DOI: 10.12677/jocr.2025.134038, PDF,   
作者: 胡正凯:浙江师范大学化学与材料科学学院,浙江 金华
关键词: 迈克尔加成反应有机合成Michael Addition Reaction Organic Synthesis
摘要: Michael加成反应是构建碳–碳键的一种重要策略,在有机合成中具有广泛的应用价值。本文系统介绍了几类常见的Michael加成,涵盖了领域前沿的光/电驱动的Michael加成,以及C-H键串联Michael加成反应等方向的发展情况,综述了不同反应类型的Michael加成反应在复杂分子构建中的应用策略,包括二羰基化合物的合成、环化反应以及串联加成反应等多个方面,同时也对目前不对称Michael加成领域进行了相应的概述。结合有机合成实际案例,文章进一步展望了该反应在有机合成领域的发展前景。
Abstract: The Michael addition reaction represents a pivotal strategy for carbon-carbon bond formation, boasting broad application value in organic synthesis. This article systematically introduces several common types of Michael additions, encompassing advancements in frontier areas such as light-/electro-driven Michael additions and C-H bond activation-triggered tandem Michael addition reactions. It reviews the application strategies of different Michael addition reaction types in the construction of complex molecules, including multiple aspects such as the synthesis of dicarbonyl compounds, cyclization reactions, and tandem addition reactions. Simultaneously, it provides a corresponding overview of the current field of asymmetric Michael additions. By integrating practical cases from organic synthesis, the article further looks into the future development potential of this reaction within the realm of organic synthesis.
文章引用:胡正凯. Michael加成反应在合成中的应用策略研究[J]. 有机化学研究, 2025, 13(4): 392-402. https://doi.org/10.12677/jocr.2025.134038

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