多囊卵巢综合征线粒体研究热点与临床转化趋势：基于CiteSpace和VOSviewer的可视化分析

Mitochondrial Research Hotspots and Clinical Translational Trends in Polycystic Ovary Syndrome: Visualisation and Analysis Based on CiteSpace and VOSviewer

摘要: 目的：本研究旨在借助文献计量学方法，对多囊卵巢综合征与线粒体的研究状况以及发展走向展开系统分析，为该领域的理论整合以及精准治疗策略给予循证依据。方法：依据Web of Science核心数据库，利用CiteSpace和VOSviewer工具，针对1702篇文献开展知识图谱分析，囊括发文量的统计、国家/地区以及机构合作网络的分析、关键词共现以及聚类分析，同时识别研究热点的演变情况。结果：PCOS线粒体研究呈现出“萌芽–增长–爆发”的三个阶段发展态势，中国以449篇的发文量位居首位，然而国际合作方面相对有所欠缺，研究热点从早期的心血管风险，逐渐转变为氧化应激、维生素D干预以及环境毒素的线粒体毒性机制，营养干预以及靶向抗氧化治疗成为新兴的研究方向。关键词聚类说明代谢综合征、炎症与线粒体功能障碍之间存在着一定的关联。结论：线粒体依靠氧化应激以及代谢失调参与到PCOS的病理进程当中，未来需要结合多组学技术以及跨学科协作，推动靶向线粒体的精准治疗以及临床转化研究。

Abstract: Objective: The aim of this study is to systematically analyse the status and evolution of research on polycystic ovary syndrome (POCS) and mitochondria using bibliometric methods in order to provide an evidence-based basis for the integration of theories and precise treatment strategies in this field. Methods: Based on the Web of Science core database, 1889 articles were analysed using CiteSpace and VOSviewer, including number of publications, analysis of country/region and institutional collaboration networks, co-occurrence of keywords and clustering analysis, and identification of research hotspots. Results: Mitochondrial research on PCOS has shown a three-stage development of “germination-growth-explosion”, with China ranking first with 449 publications, but there is a relative lack of international collaboration, and research hotspots have gradually shifted from cardiovascular risk in the early stage to mitochondrial toxicity mechanisms related to oxidative stress, vitamin D interventions and environmental toxins. Nutritional interventions and targeted antioxidant therapy are emerging research directions. Keyword clustering suggests an association between metabolic syndrome, inflammation and mitochondrial dysfunction. Conclusion: Mitochondria are involved in the pathological process of PCOS through oxidative stress and metabolic dysregulation. In the future, it is necessary to combine multi-omics technology and interdisciplinary collaboration to promote targeted mitochondrial therapy and clinical translational research.