维生素D缺乏与多囊卵巢综合征：机制、证据与治疗新视角

Vitamin D Deficiency and Polycystic Ovary Syndrome: Mechanisms, Evidence, and New Perspectives on Treatment

摘要: 多囊卵巢综合征(PCOS)是困扰众多女性的常见妇科内分泌疾病之一，其核心表现为临床或生化高雄、稀发排卵或无排卵、卵巢多囊样，并常伴有胰岛素抵抗、肥胖、脂代谢异常等问题。近年来，维生素D作为一种重要的甾体类激素，其与PCOS的关联性受到广泛关注。大量研究表明，PCOS患者普遍存在维生素D缺乏或不足，且维生素D水平与PCOS的核心病理生理机制，如胰岛素抵抗、高雄激素血症、卵泡发育障碍及慢性炎症状态等密切相关。本文旨在系统综述维生素D与PCOS相互关系的最新研究进展，深入探讨其潜在的作用机制，并总结维生素D补充治疗在PCOS管理中的临床价值与前景。

Abstract: Polycystic Ovary Syndrome (PCOS) represents a prevalent endocrine disorder affecting numerous women, characterized by clinical or biochemical hyperandrogenism, oligo-ovulation or anovulation, and polycystic ovarian morphology. It is frequently accompanied by insulin resistance, obesity, and dyslipidemia. In recent years, vitamin D, as a crucial steroid hormone, has garnered significant attention for its association with PCOS. Extensive research indicates that vitamin D deficiency or insufficiency is prevalent among PCOS patients, and vitamin D levels are closely linked to core pathophysiological mechanisms of PCOS, including insulin resistance, hyperandrogenemia, follicular developmental disorders, and chronic inflammatory states. This article aims to systematically review the latest research advancements on the interrelationship between vitamin D and PCOS, delve into the potential mechanisms of action, and summarize the clinical value and prospects of vitamin D supplementation in PCOS management.