针灸通过改善神经炎症和髓鞘损伤治疗阿尔茨海默病的研究进展
Research Progress of Acupuncture in Treating Alzheimer’s Disease by Improving Neuroinflammation and Myelin Injury
DOI: 10.12677/tcm.2025.1412760, PDF,    科研立项经费支持
作者: 荣玟迪*, 陈逸好：广州中医药大学针灸康复临床医学院，广东 广州；赵家莹#：广州中医药大学针灸康复临床医学院，广东 广州；广州中医药大学华南针灸研究中心，广东 广州
关键词: 阿尔茨海默病(AD)；针灸；神经炎症；髓鞘损伤；Alzheimer’s Disease (AD)； Acupuncture； Neuroinflammation； Myelin Injury
摘要: 阿尔茨海默病(AD)是一种常见的神经退行性疾病，目前尚无治愈方法。针灸作为一种非药物疗法，在改善AD症状方面显示出潜在的治疗价值。本文综述了针灸通过调节神经炎症和促进髓鞘再生来治疗AD的研究进展。针灸能够通过调节小胶质细胞和星形胶质细胞的功能，减轻神经炎症反应，降低炎症因子的表达，并促进抗炎因子释放。同时，针灸还能够保护髓鞘完整性，促进髓鞘相关蛋白的表达和髓鞘再生。由于神经炎症和髓鞘损伤之间存在双向调节作用，针灸通过改善神经炎症，间接减轻髓鞘损伤，进而改善了AD的症状。这些发现为AD的治疗提供了新的视角和潜在的治疗策略。
Abstract: Alzheimer’s disease (AD) is a common neurodegenerative disorder for which there is no cure. Acupuncture, as a non-pharmacologic therapy, shows potential therapeutic value in improving AD symptoms. This article reviews the research progress of acupuncture in treating AD by neuroinflammation and promoting myelin regeneration. Acupuncture can attenuate the neuroinflammatory response, reduce the expression of inflammatory factors, and promote the release of anti-inflammatory factors by modulating the function of microglia and astrocytes. Meanwhile, acupuncture is also able to protect myelin integrity and promote the expression of myelin-related proteins and myelin regeneration. Due to the bidirectional regulation between neuroinflammation and myelin injury, acupuncture indirectly reduced myelin damage by improving neuroinflammation, which in turn improved the symptoms of AD. These findings provide new perspectives and potential therapeutic strategies for the treatment of AD.
文章引用：荣玟迪, 陈逸好, 赵家莹. 针灸通过改善神经炎症和髓鞘损伤治疗阿尔茨海默病的研究进展[J]. 中医学, 2025, 14(12): 5278-5286. https://doi.org/10.12677/tcm.2025.1412760

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