基于PINK1/Parkin介导线粒体自噬探讨中医药治疗代谢相关脂肪性肝病研究进展
Exploration of Research Progress on Traditional Chinese Medicine in Treating Metabolic-Associated Fatty Liver Disease Based on PINK1/Parkin-Mediated Mitophagy
摘要: 代谢相关脂肪性肝病(MAFLD)是一类高发的代谢性疾病，现已跃居我国肝脏疾病发病率榜首，其治疗效果仍有待提升。线粒体自噬功能异常与肝脏脂质代谢紊乱存在密切关联，其中PTEN诱导假定激酶1 (pink1)/parkin通路是线粒体自噬调控的经典通路。研究表明，部分中药单体和复方可通过激活PINK1/Parkin通路，提升线粒体自噬活性，改善线粒体功能，减轻氧化应激和炎症反应从而治疗MAFLD。本研究聚焦于PINK1/Parkin信号通路，旨在阐明其调控线粒体自噬的具体机制，为中医药防治MAFLD提供理论依据并提出新思路。
Abstract: Metabolism-associated fatty liver disease (MAFLD), a group of highly prevalent metabolic disorders, has now become the liver disease with the highest incidence rate in China, and its therapeutic efficacy still needs improvement. Abnormal mitophagy is closely associated with hepatic lipid metabolism disorders, and the PINK1/Parkin pathway is a classical pathway regulating mitophagy. Studies have shown that some single herbs and compound formulations of Traditional Chinese Medicine (TCM) can treat MAFLD by activating the PINK1/Parkin pathway, enhancing mitophagy activity, improving mitochondrial function, and reducing oxidative stress and inflammatory responses. This study focuses on the PINK1/Parkin signaling pathway, aiming to elucidate its specific mechanism in regulating mitophagy, thereby providing a theoretical basis and proposing new insights for the prevention and treatment of MAFLD with TCM.
文章引用：乐佳蕴, 扈晓宇. 基于PINK1/Parkin介导线粒体自噬探讨中医药治疗代谢相关脂肪性肝病研究进展[J]. 中医学, 2025, 14(12): 5287-5294. https://doi.org/10.12677/tcm.2025.1412761

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