中医药调控肠–脑轴治疗肠易激综合征的作用机制及研究进展
Mechanisms and Research Advances in Traditional Chinese Medicine Regulation of the Gut-Brain Axis for Treating Irritable Bowel Syndrome
DOI: 10.12677/tcm.2025.1412768, PDF,    科研立项经费支持
作者: 郭沛桐：黑龙江中医药大学第一临床医学院，黑龙江 哈尔滨；李 冀*：黑龙江中医药大学基础医学院，黑龙江 哈尔滨
关键词: 肠易激综合征；肠–脑轴；中医药；神经–免疫调节；微生态调节；多靶点调控；Irritable Bowel Syndrome； Gut-Brain Axis； Traditional Chinese Medicine； Neuro-Immunomodulation； Microecological Regulation； Multi-Target Modulation
摘要: 肠易激综合征(IBS)是一种常见的功能性肠道疾病，病因复杂，肠–脑轴(GBA)在其发生发展中发挥关键作用。中医药治疗IBS具有整体性与多靶点调控的优势，强调辨证论治，能有效协同调节神经递质、炎症反应、肠道屏障与微生态平衡。本文综述中医药通过GBA改善IBS症状的机制与疗效，并探讨针灸等非药物疗法的积极前景。未来可结合多组学和人工智能等技术，推动中医药精准化与标准化治疗，提升临床疗效和患者生活质量。
Abstract: Irritable bowel syndrome (IBS) is a common functional intestinal disease with a complex etiology, and the gut-brain axis (GBA) plays a key role in its development. Traditional Chinese medicine (TCM) treatment of IBS has the advantages of holistic and multi-target regulation, emphasises evidence-based treatment, and can effectively and synergistically regulate neurotransmitters, inflammatory response, intestinal barrier and microecological balance. This article reviews the mechanism and efficacy of TCM in improving IBS symptoms through the gut-brain axis, and discusses the positive prospects of non-pharmacological therapies such as acupuncture. It is suggested that in the future, the combination of multi-omics and artificial intelligence technologies will promote the precise and standardised treatment of TCM to improve clinical efficacy and patients’ quality of life.
文章引用：郭沛桐, 李冀. 中医药调控肠–脑轴治疗肠易激综合征的作用机制及研究进展[J]. 中医学, 2025, 14(12): 5337-5345. https://doi.org/10.12677/tcm.2025.1412768

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