自噬在结直肠癌中的双重作用
The Dual Role of Autophagy in Colorectal Cancer
DOI: 10.12677/acm.2025.15123562, PDF,    科研立项经费支持
作者: 屈紫怡*, 吴师鸿, 何 佳, 罗顺莉#：湖南医药学院医学检验学院食品卫生与营养学教研室，湖南 怀化；刘又宾：湖南医药学院护理学院，湖南 怀化；罗 静：湖南医药学院临床学院，湖南 怀化
关键词: 结直肠癌；自噬；机制；双重作用；Colorectal Cancer； Autophagy； Mechanism； Dual Role
摘要: 结直肠癌(colorectal cancer, CRC)是全球范围内发病率和死亡率较高的恶性肿瘤之一，其治疗主要依赖手术切除，并以化疗、靶向治疗及免疫治疗等手段作为辅助治疗手段。然而，早期症状隐匿及普遍存在的耐药问题严重影响了患者的预后。自噬作为一种高度保守的细胞自我降解与物质回收机制，在CRC的发生、发展与治疗中展现出双重作用：一方面，自噬可通过诱导肿瘤细胞凋亡、增强免疫应答、改善治疗敏感性等方式抑制肿瘤进展；另一方面，在肿瘤晚期或特定微环境下，自噬又可促进肿瘤细胞存活、侵袭、转移及耐药。本文系统综述了自噬在CRC中的双重作用及其调控机制，重点探讨了自噬在免疫调节、代谢通路、氧化应激、DNA损伤修复等方面的作用，并分析了其在临床干预中的潜在价值，为实现CRC的精准治疗奠定基础。
Abstract: Colorectal cancer (CRC) is one of the malignant tumors with high incidence and mortality worldwide. Its treatment primarily relies on surgical resection, supplemented by chemotherapy, targeted therapy, and immunotherapy. However, the insidious nature of early symptoms and the widespread problem of drug resistance significantly affect patient prognosis. Autophagy, a highly conserved cellular self-degradation and material recycling mechanism, exhibits a dual role in the occurrence, development, and treatment of CRC: on the one hand, autophagy can inhibit tumor progression by inducing tumor cell apoptosis, enhancing immune response, and improving treatment sensitivity; on the other hand, in advanced stages of cancer or under specific microenvironments, autophagy can promote tumor cell survival, invasion, metastasis, and drug resistance. This article systematically reviews the dual role of autophagy in CRC and its regulatory mechanisms, focusing on its roles in immune regulation, metabolic pathways, oxidative stress, and DNA damage repair, and analyzes its potential value in clinical intervention, laying the foundation for achieving precision treatment of CRC.
文章引用：屈紫怡, 吴师鸿, 何佳, 刘又宾, 罗静, 罗顺莉. 自噬在结直肠癌中的双重作用[J]. 临床医学进展, 2025, 15(12): 1540-1546. https://doi.org/10.12677/acm.2025.15123562

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