肠道微生物：连接锂暴露与癫痫风险的新视角
Gut Microbiota: A Novel Perspective Linking Lithium Exposure to Epilepsy Risk
DOI: 10.12677/bp.2025.154034, PDF,   
作者: 吴祺祺：重庆医科大学公共卫生学院，重庆
关键词: 锂；肠道微生物；癫痫；Lithium； Gut Microbiota； Epilepsy
摘要: 癫痫是一种以反复发作为特征的常见神经系统疾病，具有多种危险因素和强烈遗传易感性，影响着全球超过7000万人。锂作为一种重要的碱金属元素，在现代工业中广泛应用于各种领域，尤其是随着锂离子电池产业的爆炸式增长，其在电子产品、新能源汽车和储能设备中的需求激增，导致了锂在环境中的持续释放，通过废水、废弃物和粉尘等途径进入土壤和水体，造成了普遍的低水平环境锂暴露。环境及医疗锂暴露的神经毒性日益受到关注，尤其锂的促惊厥特性提示其可能加剧神经系统兴奋性失衡，然而其机制未明。本研究通过查阅国内外文献，综述锂诱导的肠道微生态失调特征，解析菌群紊乱调控癫痫易感性的潜在机制，为理解锂的神经毒性提供了新视角，亦为癫痫防治提供了潜在新靶点。
Abstract: Epilepsy is a common neurological disorder characterized by recurrent seizures, influenced by multiple risk factors and strong genetic predisposition, affecting over 70 million people worldwide. As an important alkali metal, lithium is widely used in various modern industrial fields, especially in electronics, new energy vehicles, and energy storage devices due to the rapid expansion of the lithium-ion battery industry. This growing demand has led to continuous environmental release of lithium through wastewater, waste, and dust, resulting in widespread low-level environmental lithium exposure. Increasing attention has been drawn to the neurotoxicity of both environmental and medical lithium exposure. In particular, its proconvulsant properties suggest a potential exacerbation of neurological excitability imbalance, though the underlying mechanisms remain unclear. By reviewing domestic and international literature, this study summarizes the characteristics of lithium-induced gut microbiota dysbiosis and explores the potential mechanisms through which microbial disturbance modulates epilepsy susceptibility. The findings provide new insights into lithium’s neurotoxicity and suggest potential targets for the prevention and treatment of epilepsy.
文章引用：吴祺祺. 肠道微生物：连接锂暴露与癫痫风险的新视角[J]. 生物过程, 2025, 15(4): 265-272. https://doi.org/10.12677/bp.2025.154034

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