间歇性禁食调控肠道微生物在代谢健康中的作用与机制研究
Research on the Role and Mechanism of Intermittent Fasting in Regulating Gut Microbiota in Metabolic Health
DOI: 10.12677/bp.2025.154035, PDF,   
作者: 杨元君：重庆医科大学公共卫生学院，重庆
关键词: 间歇性禁食；肠道微生物；代谢性疾病；Intermittent Fasting； Gut Microbiota； Metabolic Disorders
摘要: 间歇性禁食(Intermittent Fasting, IF)作为一种周期性能量摄入模式，因其在改善肥胖和Ⅱ型糖尿病等代谢性疾病方面的显著效果而备受关注。近年来，研究表明间歇性禁食的代谢益处远不止于热量限制，其与肠道微生物之间的相互作用被认为是关键机制。本文系统梳理了间歇性禁食调控肠道微生物，进而影响宿主代谢健康的研究进展。间歇性禁食通过建立进食–禁食周期，显著重塑了肠道微生物的组成并优化其功能，但间歇性禁食对菌群的影响仍存在个体差异，其长期的临床转化应用前景广阔但任重而道远。深入理解IF–微生物组–宿主代谢的互作网络，将为未来开发基于肠道微生物的精准营养干预策略提供重要理论依据。
Abstract: Intermittent Fasting (IF), as a cyclical energy intake pattern, has garnered significant attention for its remarkable effects in improving metabolic disorders such as obesity and type 2 diabetes. Recent studies indicate that the metabolic benefits of intermittent fasting extend far beyond simple calorie restriction, with its interaction with the gut microbiota considered a key mechanism. This paper systematically reviews research progress on how intermittent fasting modulates gut microbiota to influence host metabolic health. By establishing eating-fasting cycles, IF significantly reshapes gut microbial composition and optimizes its function. However, individual variations in IF’s impact on the microbiome persist, and its long-term clinical translation holds great promise yet faces considerable challenges. Deepening our understanding of the IF-microbiome-host metabolism interaction network will provide crucial theoretical foundations for developing future precision nutrition intervention strategies based on gut microbiota.
文章引用：杨元君. 间歇性禁食调控肠道微生物在代谢健康中的作用与机制研究 [J]. 生物过程, 2025, 15(4): 273-281. https://doi.org/10.12677/bp.2025.154035

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