基于ANSYS的肠道仿真模型的建模与仿真

Modeling and Simulation of an Intestinal Model Based on ANSYS

摘要: 肠道是食物与药物消化吸收的关键器官。随着美国食品药品监督管理局(FDA)取消动物实验作为临床前研究的强制要求，建立高仿真的体外肠道模型成为研究肠道功能的重要方向。本研究构建了一种包含绒毛结构、支持流体剪切力及蠕动模拟的仿真模型。基于ANSYS Workbench平台，利用Fluent分析绒毛高度、间距和入口流速对剪切应力的影响，并通过流固耦合模拟探讨蠕动效应。结果显示，绒毛高度增加会增强剪切应力并加剧流场不均；而增大绒毛间距有助于改善流动特性、降低流体阻力，从而有效调控剪切应力。同时，剪切应力随流速线性上升，但在蠕动作用下受到明显抑制，并呈现压力阈值特征。

Abstract: The intestine is a key organ responsible for the digestion and absorption of food and drugs. With the U.S. Food and Drug Administration (FDA) lifting the mandatory requirement for animal testing in preclinical studies, the development of highly biomimetic in vitro intestinal models has become a vital direction for investigating intestinal function. This study presents a simulation model that incorporates villus structures and supports both fluid shear stress and peristalsis simulation. Using the ANSYS Workbench platform, Fluent was employed to analyze the effects of villus height, spacing, and inlet flow velocity on shear stress, while fluid-structure interaction (FSI) simulations were conducted to explore the impact of peristalsis. The results indicate that increased villus height enhances shear stress and intensifies flow field heterogeneity, whereas wider villus spacing improves flow characteristics and reduces fluid resistance, thereby effectively modulating shear stress. Additionally, shear stress increases linearly with flow velocity but is significantly suppressed under peristaltic motion, exhibiting a distinct pressure threshold behavior.