肠道菌群介导的炎癌转化及肠癌发生中STAT3作用机制的探讨

Exploration of the Mechanism of STAT3 in Intestinal Flora-Mediated Inflammation-Cancer Transformation and Colorectal Cancer Onset

摘要: 结直肠癌(CRC)是全球发病率和死亡率都很高的恶性肿瘤，肠道菌群失调和慢性肠道炎症是肠癌发生的关键因素，二者因“炎癌转化”这个核心病理过程紧密联系，信号转导与转录激活因子3 (STAT3)是细胞里的关键信号之一，在免疫调节、细胞生长、死亡和炎症反应中起到关键性作用，本文主要从代谢产物、炎症通路，探讨肠道菌群在STAT3活化中的调控作用，探讨STAT3在菌群失调引起的肠道炎症、炎癌转化和肠癌发生发展中的分子机制，还展望靶向STAT3和调控肠道菌群结合的肠癌防治新方法，给肠癌的基础研究和临床干预提供新论点。

Abstract: Colorectal cancer (CRC) is a malignant tumor with high incidence and mortality rates worldwide. Intestinal flora dysbiosis and chronic intestinal inflammation are key factors in the development of colorectal cancer, and the two are closely linked through the core pathological process of “inflammation-cancer transformation”. Signal Transducer and Activator of Transcription 3 (STAT3) is one of the key signaling molecules in cells and plays a crucial role in immune regulation, cell growth, cell death, and inflammatory responses. This article mainly discusses the regulatory role of intestinal flora in STAT3 activation from the perspectives of metabolites and inflammatory pathways, explores the molecular mechanisms of STAT3 in intestinal inflammation, inflammation-cancer transformation and the occurrence and development of colorectal cancer induced by flora imbalance, and prospects new methods for the prevention and treatment of colorectal cancer combining targeted STAT3 and intestinal flora regulation, so as to provide new arguments for the basic research and clinical intervention of colorectal cancer.