肺腺癌分子病理研究的前沿展望

Future Directions in the Molecular Pathological Landscape of Lung Adenocarcinoma

摘要: 肺癌是全球发病率和死亡率最高的恶性肿瘤之一，非小细胞肺癌(NSCLC)占肺癌病例的85%以上，肺癌的发生和发展是一个多阶段、多因素的过程，与多种驱动基因的突变或重排密切相关。其中，肺腺癌是一种常见的肺癌类型，其发病率和死亡率在全球范围内均呈上升趋势。近年来，随着基因测序和分子生物学技术的飞速发展，越来越多的研究开始关注肺腺癌的发病机制，尤其是与基因变异、基因表达调控等方面的研究。本文旨在综述近年来肺腺癌基因研究进展，以期为肺腺癌的预防和治疗提供新的思路。

Abstract: Lung cancer ranks among the most prevalent and deadly malignancies worldwide. Non-small cell lung cancer (NSCLC) accounts for over 85% of all lung cancer cases. The pathogenesis of lung cancer is a multi-stage and multi-factorial process, closely associated with mutations or rearrangements in various driver genes. As a major histological subtype, the incidence and mortality of lung adenocarcinoma (LUAD) have been rising globally. In recent years, advancements in gene sequencing and molecular biology have spurred extensive research into the mechanisms of LUAD, particularly focusing on genetic alterations and the regulation of gene expression. This review aims to summarize recent progress in the genetic study of lung adenocarcinoma, hoping to provide new insights for its prevention and treatment.