新型胰岛素抵抗评价指标在代谢性疾病中的应用及预测潜力
Application and Predictive Potential of Novel Insulin Resistance Assessment Indices in Metabolic Diseases
摘要: 代谢性疾病以糖、脂、蛋白质及嘌呤等物质代谢异常为特征，涵盖高血压、高血糖、高血脂、脂肪肝、痛风及心血管疾病等。胰岛素抵抗(IR)被广泛认为是贯穿此类疾病发生发展的核心病理机制，早期干预IR对阻断代谢紊乱进程至关重要。近年来，多种基于常规检测参数的新型IR评价指标因其便捷性和良好的预测效能受到关注，如甘油三酯葡萄糖指数(TyG)、甘油三酯葡萄糖–体质指数(TyG-BMI)、TyG-腰围指数(TyG-WC)、TyG-腰高比(TyG-WHtR)及甘油三酯/高密度脂蛋白胆固醇比值(TG/HDL-C)等。本文旨在综述这些新型IR评价指标在各类代谢性疾病中的应用及预测潜力，为代谢性疾病早期识别、风险预警及预后评估提供理论依据和参考。
Abstract: Metabolic diseases are characterized by disorders in the metabolism of carbohydrates, lipids, proteins, purines, and related substances, encompassing conditions such as hypertension, hyperglycemia, dyslipidemia, fatty liver disease, gout, and cardiovascular diseases. Insulin resistance (IR) is widely recognized as a core pathophysiological mechanism underlying the development and progression of these disorders. Early intervention targeting IR is critical for halting the cascade of metabolic dysregulation. In recent years, novel IR assessment indicators derived from routine clinical parameters—such as the triglyceride-glucose index (TyG), TyG-body mass index (TyG-BMI), TyG-waist circumference (TyG-WC), TyG-waist-to-height ratio (TyG-WHtR), and triglyceride to high-density lipoprotein cholesterol ratio (TG/HDL-C)—have garnered significant attention due to their accessibility and robust predictive utility. This review aims to summarize the application and predictive potential of these novel IR assessment indices across various metabolic diseases, thereby providing a theoretical foundation and reference for early identification, risk warning, and prognosis evaluation of metabolic disorders.
文章引用：郑莹莹, 裴萌萌, 程丽霞. 新型胰岛素抵抗评价指标在代谢性疾病中的应用及预测潜力[J]. 临床医学进展, 2025, 15(12): 2174-2184. https://doi.org/10.12677/acm.2025.15123641

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