中药调控Hippo信号通路干预乳腺癌的研究进展
Progress in Prevention and Treatment of Breast Cancer by Traditional Chinese Medicine Targeting Hippo Signaling Pathway
DOI: 10.12677/acm.2025.15123649, PDF,   
作者: 赵陆轶：黑龙江中医药大学，第一临床医学院，黑龙江 哈尔滨；刘松江*：黑龙江中医药大学附属第一医院，肿瘤科，黑龙江 哈尔滨
关键词: 乳腺癌；Hippo信号通路；中医药；作用机制；研究进展；Breast Cancer； Hippo Signaling Pathway； Traditional Chinese Medicine； Action Mechanism； Research Progress
摘要: 乳腺癌(Breast cancer)是女性癌症中最常见的一种，其发病率和死亡率逐年持续升高，治疗方式目前以手术、化疗、靶向治疗、免疫治疗为主，但易出现晚期转移、耐药性等问题。Hippo通路是通过协调机械、代谢、细胞内外信号，调节细胞增殖分化与凋亡、器官生长、组织再生及伤口愈合等生理功能的保守信号通路。在BC中，Hippo通路的主要成分在细胞水平上的失调可诱导多个异常病理过程以促进BC的发展、转移和耐药。中药因其多靶点、多机制的特点在癌症的辅助治疗中具有重要地位。研究发现，中药单体中的萜类、皂苷类、酚类、生物碱类、黄酮类、核苷类化合物，中药提取物中的槐耳水提取物、紫苏叶提取物，中药复方中的复方苦参注射液、乳康饮均能通过调控Hippo信号通路，通过抑制细胞增殖分化及迁移、促进细胞凋亡、抑制干细胞干性、抑制上皮–间充质转化等机制对BC有一定治疗作用。本文通过归纳总结近年来中药靶向Hippo通路治疗BC的研究成果，旨在为后续研究和新药开发提供思路。
Abstract: Breast cancer is the most common type of female cancer, and its morbidity and mortality rates continue to increase year by year. Treatment is currently based on surgery, chemotherapy, targeted therapy, and immunotherapy, but it is prone to late metastasis and drug resistance. The Hippo pathway is a conserved signaling pathway that regulates cellular proliferation, differentiation and apoptosis, organ growth, tissue regeneration, and wound healing by coordinating mechanical, metabolic, and intra- and extracellular signals. In BC, dysregulation of the main components of the Hippo pathway at the cellular level can induce several abnormal pathological processes to promote the development, metastasis, and drug resistance of BC. Traditional Chinese medicine (TCM) has an important role in the adjuvant treatment of cancer due to its multi-target and multi-mechanism characteristics. It has been found that terpenoids, saponins, phenols, alkaloids, flavonoids, and nucleosides in TCM monomers, Sophora Japonica Water Extract and Extracts of Perilla frutescens var. Acuta (Odash) Kudo Leaves in TCM extracts, and Mechanism of Compound Kushen Injection and RuKang Yin in TCM compounds can have certain therapeutic effects on BC through regulating the Hippo signaling pathway by inhibiting cell proliferation and differentiation, migration, promoting apoptosis, inhibiting stem cell stemness, and inhibiting epithelial-mesenchymal transition. In this paper, we summarise the research results on the targeting of the Hippo pathway by traditional Chinese medicine in the treatment of BC in recent years, to provide ideas for subsequent research and new drug development.
文章引用：赵陆轶, 刘松江. 中药调控Hippo信号通路干预乳腺癌的研究进展[J]. 临床医学进展, 2025, 15(12): 2238-2249. https://doi.org/10.12677/acm.2025.15123649

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