残余胆固醇与瓣膜钙化对女性冠心病的相关性
Correlation between Remnant Cholesterol and Valve Calcification with Female Coronary Artery Disease
DOI: 10.12677/acm.2025.15123650, PDF,   
作者: 岳鑫鑫*, 赵天资:承德医学院研究生院,河北 承德;张华龙#:邢台市人民医院心脏内六科,河北 邢台
关键词: 残余胆固醇心脏瓣膜钙化女性冠心病诊断预后Remnant Cholesterol Cardiac Valve Calcification Female Coronary Artery Disease Diagnosis Prognosis
摘要: 冠心病(coronary artery disease, CAD)是一种严重威胁人类健康的心血管疾病,女性CAD在发病机制、临床表现、诊断及预后等方面与男性存在差异。残余胆固醇(remnant cholesterol, RC)作为脂质代谢的重要指标,以及心脏瓣膜钙化作为心血管系统的一种病理改变,均与CAD的发生发展密切相关。本文旨在探讨RC与瓣膜钙化对女性CAD在诊断、评估疾病严重程度及预测预后方面的价值,为临床实践中女性CAD的精准防治提供理论依据。
Abstract: Coronary artery disease (CAD) is a cardiovascular disease that seriously threatens human health. Female CAD differs from male CAD in terms of pathogenesis, clinical manifestations, diagnosis, and prognosis. Remnant cholesterol (RC), as an important indicator of lipid metabolism, and cardiac valve calcification, as a pathological change in the cardiovascular system, are both closely related to the occurrence and development of CAD. This article aims to explore the value of RC and valve calcification in the diagnosis, assessment of disease severity, and prediction of prognosis of female CAD, so as to provide a theoretical basis for the precise prevention and treatment of female CAD in clinical practice.
文章引用:岳鑫鑫, 赵天资, 张华龙. 残余胆固醇与瓣膜钙化对女性冠心病的相关性[J]. 临床医学进展, 2025, 15(12): 2250-2254. https://doi.org/10.12677/acm.2025.15123650

参考文献

[1] 李雷, 孙怡咪, 刘刚. 冠脉CTA定量参数与冠心病患者疾病进展和预后的关系[J]. 海南医学, 2022, 33(20): 2672-2675.
[2] Roth, G.A., Mensah, G.A., Johnson, C.O., et al. (2020) Global Burden of Cardiovascular Diseases and Risk Factors, 1990-2019: Update from the GBD 2019 Study. Journal of the American College of Cardiology, 76, 2982-3021.
[3] Safiri, S., Karamzad, N., Singh, K., Carson-Chahhoud, K., Adams, C., Nejadghaderi, S.A., et al. (2021) Burden of Ischemic Heart Disease and Its Attributable Risk Factors in 204 Countries and Territories, 1990-2019. European Journal of Preventive Cardiology, 29, 420-431. [Google Scholar] [CrossRef] [PubMed]
[4] 刘明波, 何新叶, 杨晓红, 王增武. 《中国心血管健康与疾病报告2024》要点解读[J]. 心肺血管病杂志, 2025, 44(9): 899-917.
[5] Wang, X., Gao, M., Zhou, S., Wang, J., Liu, F., Tian, F., et al. (2017) Trend in Young Coronary Artery Disease in China from 2010 to 2014: A Retrospective Study of Young Patients ≤ 45. BMC Cardiovascular Disorders, 17, Article No. 18. [Google Scholar] [CrossRef] [PubMed]
[6] Burgess, S.N. (2022) Understudied, Under-Recognized, Underdiagnosed, and Undertreated: Sex-Based Disparities in Cardiovascular Medicine. Circulation: Cardiovascular Interventions, 15, e011714. [Google Scholar] [CrossRef] [PubMed]
[7] Wenger, N.K., Lloyd-Jones, D.M., Elkind, M.S.V., Fonarow, G.C., Warner, J.J., Alger, H.M., et al. (2022) Call to Action for Cardiovascular Disease in Women: Epidemiology, Awareness, Access, and Delivery of Equitable Health Care: A Presidential Advisory from the American Heart Association. Circulation, 145, e1059-e1071. [Google Scholar] [CrossRef] [PubMed]
[8] 查志敏, 刘欢, 王向明, 李秋爽, 郭妍. 心脏瓣膜钙化对老年冠心病病人预后的影响[J]. 实用老年医学, 2024, 38(3): 245-250.
[9] Saran, N., Greason, K.L., Schaff, H.V., Cicek, S.M., Daly, R.C., Maltais, S., et al. (2019) Does Mitral Valve Calcium in Patients Undergoing Mitral Valve Replacement Portend Worse Survival? The Annals of Thoracic Surgery, 107, 444-452. [Google Scholar] [CrossRef] [PubMed]
[10] 陈焱, 徐清, 周庆志, 等. 残余胆固醇对血压正常高值冠心病患者发生MACCE的临床预后价值[J]. 中国动脉硬化杂志, 2022, 30(10): 878-883.
[11] Li, X., Li, Z. and Wu, N. (2025) Remnant Cholesterol and Residual Risk of Atherosclerotic Cardiovascular Disease. Reviews in Cardiovascular Medicine, 26, Article No. 25985. [Google Scholar] [CrossRef] [PubMed]
[12] Riis, J., Nordestgaard, B.G. and Afzal, S. (2025) High Remnant Cholesterol and Atherosclerotic Cardiovascular Disease in Healthy Women and Men Aged 70-100. European Journal of Preventive Cardiology, 32, 1169-1177. [Google Scholar] [CrossRef] [PubMed]
[13] Zhang, Y., Song, K., Bi, S., Li, M. and Yao, Z. (2024) Higher Remnant Cholesterol Increases the Risk of Coronary Heart Disease and Diabetes in Postmenopausal Women. Frontiers in Endocrinology, 15, Article ID: 1475933. [Google Scholar] [CrossRef] [PubMed]
[14] 文玉鑫. 老年退行性心脏瓣膜病临床分析[D]: [硕士学位论文]. 南宁: 广西医科大学, 2021.
[15] Aronow, W.S., Ahn, C. and Kronzon, I. (1999) Association of Mitral Annular Calcium and of Aortic Cuspal Calcium with Coronary Artery Disease in Older Patients. The American Journal of Cardiology, 84, 1084-1085. [Google Scholar] [CrossRef] [PubMed]
[16] Jiang, C., Yao, D., Shen, Q., Tian, R., Fan, L., Zheng, Q., et al. (2025) Oxidized LDL-Induced FOXS1 Mediates Cholesterol Transport Dysfunction and Inflammasome Activation to Drive Aortic Valve Calcification. Cardiovascular Research, 121, 1941-1955. [Google Scholar] [CrossRef
[17] Lerman, D.A., Prasad, S. and Alotti, N. (2015) Calcific Aortic Valve Disease: Molecular Mechanisms and Therapeutic Approaches. European Cardiology Review, 10, 108-112. [Google Scholar] [CrossRef] [PubMed]