基于PI3K/AKT信号通路的中医药治疗胃癌的研究进展
Research Progress on Traditional Chinese Medicine Treatment of Gastric Cancer Based on the PI3K/AKT Signaling Pathway
DOI: 10.12677/jcpm.2026.51001, PDF,   
作者: 云 灿*：黑龙江中医药大学研究生院，黑龙江 哈尔滨；李 雨#：黑龙江中医药大学附属第一医院肿瘤一科，黑龙江 哈尔滨
关键词: 胃癌；PI3K/AKT信号通路；中医药；靶向治疗；机制研究；Gastric Cancer； PI3K/AKT Signaling Pathway； Traditional Chinese Medicine； Targeted Therapy； Mechanistic Research
摘要: 胃癌作为全球高发且致死率居高不下的恶性肿瘤，其诊治依然面临诸多困难。PI3K/AKT信号通路在胃癌细胞的增殖、凋亡、转移及耐药等过程中起着核心调控作用，成为当前靶向治疗的重点靶标。中医药凭借其多成分、多靶点的特性，在调节PI3K/AKT通路方面展现出独特优势和广阔应用前景。本文系统回顾了PI3K/AKT信号通路在胃癌发生发展中的分子机制，重点总结了近年来中医药在调控该通路以抑制胃癌进展的研究成果，分析其潜在的治疗机制及临床应用价值。旨在为中医药靶向胃癌的创新治疗策略提供理论支持和研究参考，推动相关领域的深入发展。
Abstract: Gastric cancer, as a highly prevalent and fatal malignant tumor worldwide, still faces numerous challenges in diagnosis and treatment. The PI3K/AKT signaling pathway plays a core regulatory role in the proliferation, apoptosis, metastasis, and drug resistance of gastric cancer cells, making it a key target for current targeted therapy. Traditional Chinese Medicine (TCM), with its multi-component and multi-target characteristics, has demonstrated unique advantages and broad application prospects in regulating the PI3K/AKT pathway. This paper systematically reviews the molecular mechanisms of the PI3K/AKT signaling pathway in the occurrence and development of gastric cancer, focusing on summarizing the research achievements in recent years on how TCM regulates this pathway to inhibit gastric cancer progression. It analyzes its potential therapeutic mechanisms and clinical application value. The aim is to provide theoretical support and research references for the innovative targeted treatment strategies of TCM for gastric cancer, promoting in-depth development in this field.
文章引用：云灿, 李雨. 基于PI3K/AKT信号通路的中医药治疗胃癌的研究进展[J]. 临床个性化医学, 2026, 5(1): 1-8. https://doi.org/10.12677/jcpm.2026.51001

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