中医药基于HIF-1α治疗糖尿病肾病的研究进展
Research Progress of Treatment of Diabetic Kidney Disease Based on HIF-1α in Traditional Chinese Medicine
DOI: 10.12677/jcpm.2026.51002, PDF,   
作者: 张小骞：黑龙江中医药大学研究生院，黑龙江 哈尔滨；宋立群*：黑龙江中医药大学附属第一医院门诊部，黑龙江 哈尔滨
关键词: 糖尿病肾病；缺氧诱导因子-1α；氧化应激；血红素加氧酶-1；血管内皮生长因子；Diabetic Kidney Disease； Hypoxia-Inducing Factor-1α； Oxidative Stress； Heme Oxygenase-1； Vascular Endothelial Growth Factor
摘要: 糖尿病肾病是由糖尿病引起的微血管病变，已逐渐成为终末期肾病的主要原因。缺氧诱导因子-1α (HIF-1α)是维持氧稳态的核心转录因子，在高糖低氧环境下，其表达增加，诱导下游靶基因的表达，通过影响细胞外基质沉积、血管生成、铁代谢等介导糖尿病肾病的发展。中医药在治疗糖尿病肾病中的作用已得到大量实验研究的验证，本文结合近年的相关文献综述HIF-1α在糖尿病肾病中的作用机制以及通过中医药调控HIF-1α起到延缓糖尿病肾病的进展，为中医药治疗糖尿病肾病提供新策略。
Abstract: Diabetic kidney disease is a microvascular disease caused by diabetes, which has gradually become the main cause of end-stage nephropathy. Hypoxia-inducing factor-1α (HIF-1α) is the core transcription factor that maintains oxygen homeostasis. In the environment of high glucose and low oxygen, its expression increases, inducing the expression of downstream target genes, and mediating the occurrence and development of diabetic kidney disease by affecting extracellular matrix deposition, angiogenesis and iron metabolism. The role of traditional Chinese medicine in the treatment of diabetic kidney disease has been verified by a large number of experimental studies. In this paper, the mechanism of HIF-1α in diabetic kidney disease and the delay of the progression of diabetic kidney disease through the regulation of HIF-1α by traditional Chinese medicine are reviewed in combination with the relevant literature in recent years, so as to provide a new strategy for the treatment of diabetic kidney disease with traditional Chinese medicine.
文章引用：张小骞, 宋立群. 中医药基于HIF-1α治疗糖尿病肾病的研究进展[J]. 临床个性化医学, 2026, 5(1): 9-17. https://doi.org/10.12677/jcpm.2026.51002

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