妊娠合并复杂先天性心脏病1例
A Case Report: Pregnancy Complicated with Complex Congenital Heart Disease
DOI: 10.12677/jcpm.2026.51005, PDF,   
作者: 刘 萌*, 付红伟, 赵佳欣：济宁医学院临床医学院(附属医院)，山东 济宁；冯雪芹, 满冬梅#：济宁医学院附属医院产科，山东 济宁
关键词: 妊娠；先天性心脏病；艾森曼格综合症；Pregnancy； Congenital Heart Disease； Eisenmenger Syndrome
摘要: 本文报道1例患有未经矫正的复杂先天性心脏病(CCHD)的未生育女性。在心脏病专家、产科医生和重症监护专家进行了积极治疗后，病情仍恶化为心力衰竭，并导致了胎儿宫内死亡。最终通过终止妊娠的剖宫产手术稳定了她的血流动力学。该病例突显了未经矫正的CCHD患者妊娠期间母胎面临的重大风险，并强调了需要积极的产前咨询、使用经过验证的框架进行全面风险评估以及制定个性化的多学科护理路径，以减少危及生命的并发症。
Abstract: This case report describes a 24-year-old nulliparous woman with uncorrected complex congenital heart disease (CCHD). Despite intensive management by cardiologists, obstetricians, and critical care specialists, her condition deteriorated into heart failure, leading to intrauterine fetal death. Cesarean delivery for pregnancy termination ultimately stabilized her hemodynamics. This case highlights the significant maternal-fetal risks associated with pregnancy in patients with uncorrected CCHD and emphasizes the need for proactive prenatal counseling, thorough risk assessment using validated frameworks, and tailored multidisciplinary care pathways to reduce life-threatening complications.
文章引用：刘萌, 付红伟, 赵佳欣, 冯雪芹, 满冬梅. 妊娠合并复杂先天性心脏病1例[J]. 临床个性化医学, 2026, 5(1): 30-34. https://doi.org/10.12677/jcpm.2026.51005

参考文献

[1] Williams, K., Carson, J. and Lo, C. (2019) Genetics of Congenital Heart Disease. Biomolecules, 9, Article No. 879. [Google Scholar] [CrossRef] [PubMed]
[2] Wander, G., van der Zande, J.A., Patel, R.R., Johnson, M.R. and Roos-Hesselink, J. (2023) Pregnancy in Women with Congenital Heart Disease: A Focus on Management and Preventing the Risk of Complications. Expert Review of Cardiovascular Therapy, 21, 587-599. [Google Scholar] [CrossRef] [PubMed]
[3] Bishop, L., Lansbury, A. and English, K. (2018) Adult Congenital Heart Disease and Pregnancy. BJA Education, 18, 23-29. [Google Scholar] [CrossRef] [PubMed]
[4] Galiè, N., Humbert, M., Vachiery, J., Gibbs, S., Lang, I., Torbicki, A., et al. (2015) 2015 ESC/ERS Guidelines for the Diagnosis and Treatment of Pulmonary Hypertension. European Heart Journal, 37, 67-119. [Google Scholar] [CrossRef] [PubMed]
[5] Broberg, C.S. (2016) Challenges and Management Issues in Adults with Cyanotic Congenital Heart Disease. Heart, 102, 720-725. [Google Scholar] [CrossRef] [PubMed]
[6] Gupta, V., Tonelli, A.R. and Krasuski, R.A. (2012) Congenital Heart Disease and Pulmonary Hypertension. Heart Failure Clinics, 8, 427-445. [Google Scholar] [CrossRef] [PubMed]
[7] Baroutidou, A., Arvanitaki, A., Hatzidakis, A., Pitsiou, G., Ziakas, A., Karvounis, H., et al. (2022) Haemoptysis in Pulmonary Arterial Hypertension Associated with Congenital Heart Disease: Insights on Pathophysiology, Diagnosis and Management. Journal of Clinical Medicine, 11, Article No. 633. [Google Scholar] [CrossRef] [PubMed]
[8] Wang, K., Luo, H., Xin, Y. and Yu, H. (2015) Successful Pregnancy and Delivery in Patients with Uncorrected Single Ventricle: Three New Cases and Literature Review. International Journal of Cardiology, 184, 135-139. [Google Scholar] [CrossRef] [PubMed]
[9] Boukhris, M., Hakim, K., M’saad, H., Ouarda, F. and Boussaada, R. (2013) Successful Pregnancy and Delivery in a Woman with a Single Ventricle and Eisenmenger Syndrome. Journal of the Saudi Heart Association, 25, 261-264. [Google Scholar] [CrossRef] [PubMed]
[10] Regitz-Zagrosek, V., Roos-Hesselink, J.W., Bauersachs, J., Blomström-Lundqvist, C., Cífková, R., De Bonis, M., et al. (2018) 2018 ESC Guidelines for the Management of Cardiovascular Diseases during Pregnancy. European Heart Journal, 39, 3165-3241. [Google Scholar] [CrossRef] [PubMed]