济生肾气丸治疗慢性肾脏病的研究进展

Research Progress on Jisheng Shenqi Pills in the Treatment of Chronic Kidney Disease

摘要: 中医认为慢性肾脏病属于“水肿”“虚劳”“关格”及“癃闭”等传统病证范畴，其病机根本在于“肾虚”。济生肾气丸源自南宋医家严用和所著《济生方·卷四·水肿门》，原方主要用于肾虚所致水肿、腰膝酸软、小便不利等症。近年来，该方在慢性肾脏病治疗中的临床应用与实验研究日益受到关注，相关药理机制和疗效评价不断得到拓展与深化。本文通过综述近年来的相关文献，旨在为济生肾气丸应用于慢性肾脏病的防治提供理论参考与临床依据。

Abstract: Traditional Chinese Medicine (TCM) classifies chronic kidney disease (CKD) under the categories of “edema”, “asthenia”, “guan ge”, and “urinary retention”, with the fundamental pathogenesis attributed to “kidney deficiency”. Jisheng Shenqi Pills, originating from the “Edema” chapter of the “Jisheng Fang” by Yan Yonghe during the Southern Song Dynasty, is primarily prescribed for symptoms such as edema, lower back and knee weakness, and dysuria caused by kidney deficiency. In recent years, the clinical application and experimental research of this formula in the treatment of CKD have garnered increasing attention, with related pharmacological mechanisms and efficacy evaluations continuously expanding and deepening. This review aims to provide theoretical references and clinical evidence for the application of Jisheng Shenqi Pills in the prevention and treatment of CKD by summarizing recent relevant literature.