阿尔茨海默病连续疾病谱影像组学研究进展
Research Progress of Radiomics in the Continuous Disease Spectrum of Alzheimer’s Disease
DOI: 10.12677/acm.2025.15123697, PDF,    科研立项经费支持
作者: 刘聪聪, 韩志远：济宁医学院临床医学院(附属医院)，山东 济宁；宋 莉*, 盛 灿：济宁医学院附属医院神经内科，山东 济宁；梁 圆：黄河水利委员会黄河中心医院，河南 郑州
关键词: 阿尔茨海默病；神经影像学；影像组学；磁共振成像；氟脱氧葡萄糖正电子发射断层显像；Alzheimer’s Disease； Neuroimaging； Radiomics； Magnetic Resonance Imaging； Fluorodeoxyglucose Positron Emission Tomography
摘要: 阿尔茨海默病(Alzheimer’s disease, AD)是全球老龄化社会中的主要健康挑战之一，伴随着认知功能的逐渐丧失，严重影响患者的生活质量和社会功能。AD的发病机制复杂，涉及多个病理阶段，包括临床前期、轻度认知功能障碍(mild cognitive impairment, MCI)期以及AD痴呆阶段。早期识别AD，尤其是MCI阶段，对于疾病干预至关重要。近年来，影像组学作为一种新兴的医学图像分析技术，得到了广泛的应用与研究。通过对大量医学影像数据进行定量分析，影像组学能够提取出细致的疾病影像特征，提供潜在的生物标志物，从而在AD的早期诊断、病情评估和预后预测等方面具有巨大的潜力。本文就阿尔茨海默病连续疾病谱影像组学研究进行综述。
Abstract: Alzheimer’s disease (AD) is one of the major health challenges in the global aging society. Accompanied by the gradual loss of cognitive function, it seriously impairs patients’ quality of life and social functioning. The pathogenesis of AD is complex, involving multiple pathological stages, including the preclinical stage, mild cognitive impairment (MCI) stage, and AD dementia stage. Early identification of AD, especially in the MCI stage, is crucial for disease intervention. In recent years, radiomics, as an emerging medical image analysis technology, has been widely applied and studied. By quantitatively analyzing large amounts of medical imaging data, radiomics can extract detailed disease imaging features and provide potential biomarkers, thus holding great potential in the early diagnosis, disease assessment, and prognosis prediction of AD. This article provides a review of the research on the continuum of Alzheimer’s disease within the framework of radiomics.
文章引用：刘聪聪, 宋莉, 梁圆, 韩志远, 盛灿. 阿尔茨海默病连续疾病谱影像组学研究进展[J]. 临床医学进展, 2025, 15(12): 2632-2638. https://doi.org/10.12677/acm.2025.15123697

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