间充质干细胞及其外泌体在慢性肾脏病中的研究进展
Research Progress on Mesenchymal Stem Cells and Their Exosomes in Chronic Kidney Disease
DOI: 10.12677/jcpm.2026.51016, PDF,   
作者: 石文杰：黑龙江省中医药科学院，肾病一科，黑龙江 哈尔滨；郑佳新*：黑龙江中医药大学附属第二医院肾病二科，黑龙江 哈尔滨
关键词: 间充质干细胞；外泌体；治疗；慢性肾脏病；研究进展；Mesenchymal Stem Cells； Exosomes； Therapy； Chronic Kidney Disease； Research Progress
摘要: 慢性肾脏病(chronic kidney disease, CKD)是一个复杂的病理生理过程，肾脏微血管内皮细胞损伤、炎症反应、纤维化是发生CKD的主要原因，间充质干细胞(mesenchymal stem cells, MSCs)及其外泌体(MSCs-exosomes, MSCs-EXO)因其具有免疫调节和促生存的特性，现已成为治疗CKD的一种新兴治疗方式。它们可以通过分泌多种抗炎因子来抑制炎症的发生，促进疾病的缓解。近年来也被广泛应用于临床。但其中许多机制尚不清楚，需要我们进一步探索和研究。因此本文就MSCs及MSCs-EXO在CKD中的作用机制及研究进展作一综述，供临床医师参考。
Abstract: Chronic kidney disease (CKD) is a complex pathophysiological process, with renal microvascular endothelial cell injury, inflammatory responses, and fibrosis being the main causes of CKD. Mesenchymal stem cells (MSCs) and their exosomes (MSCs-exosomes, MSCs-EXO), due to their immune-regulatory and pro-survival properties, have become an emerging therapeutic approach for CKD. They can inhibit inflammation and promote disease remission by secreting various anti-inflammatory factors. In recent years, they have also been widely applied in clinical practice. However, many of the underlying mechanisms remain unclear and require further exploration and research. Therefore, this paper reviews the mechanisms and research progress of MSCs and MSCs-EXO in CKD, providing a reference for clinical physicians.
文章引用：石文杰, 郑佳新. 间充质干细胞及其外泌体在慢性肾脏病中的研究进展[J]. 临床个性化医学, 2026, 5(1): 102-109. https://doi.org/10.12677/jcpm.2026.51016

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