混合系列蛋白激酶样结构域在心血管疾病中的研究进展
Research Progress of Mixed Lineage Kinase Domain Like Protein in Cardiovascular Diseases
摘要: 坏死性凋亡途径是一种受体相互作用蛋白1 (receptor interacting protein kinase 1, RIPK1)、受体相互作用蛋白13 (receptor interacting protein kinase 3, RIPK3)、混合系列蛋白激酶样结构域(mixed lineage kinase domain like protein, MLKL)信号通路介导的不依赖半胱氨酸蛋白酶(caspase)的程序性细胞坏死死亡方式之一。MLKL在坏死性凋亡途径中起执行分子的作用，其在心血管疾病、癌症等病理过程中起着重要作用。在这篇文章中，我们概述了坏死性凋亡执行分子MLKL的分子机制，强调了其复杂的调节和执行的最新观点，以及在心血管相关疾病的研究进展。
Abstract: Necroptosis is a form of programmed necrotic cell death mediated by a signaling pathway involving receptor-interacting protein kinase 1 (RIPK1), receptor-interacting protein kinase 3 (RIPK3), and mixed lineage kinase domain-like protein (MLKL), which is independent of caspase proteases. MLKL plays an executioner role in the necroptotic pathway and is significantly involved in pathological processes such as cardiovascular diseases and cancer. In this article, we summarize the molecular mechanisms of the necroptosis executioner MLKL, emphasizing the latest views on its complex regulation and execution, as well as research progress in cardiovascular-related diseases.
文章引用：尹耀想, 张爱文. 混合系列蛋白激酶样结构域在心血管疾病中的研究进展[J]. 临床医学进展, 2026, 16(1): 58-63. https://doi.org/10.12677/acm.2026.161008

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