矮小症儿童甲状腺激素敏感性评估及其与IGF-1/IGFBP-3轴关联的研究进展
Research Progress on Thyroid Hormone Sensitivity Assessment in Children with Short Stature and Its Association with the IGF-1/IGFBP-3 Axis
DOI: 10.12677/jcpm.2026.51030, PDF,   
作者: 朱俊珂：济宁医学院临床医学院(附属医院)，山东 济宁；李 萍*：济宁医学院附属医院内分泌科，山东 济宁
关键词: 矮小症；甲状腺激素敏感性；IGF-1/IGFBP-3轴；表观遗传调控；Short Stature； Thyroid Hormone Sensitivity； IGF-1/IGFBP-3 Axis； Epigenetic Regulation
摘要: 矮小症是儿童内分泌领域常见疾病，其发病机制涉及多种内分泌轴功能异常。近年来，甲状腺激素敏感性评估在矮小症诊疗中的价值日益受到关注。本文系统综述了甲状腺激素敏感性评估方法及其与胰岛素样生长因子-1 (IGF-1)/胰岛素样生长因子结合蛋白-3 (IGFBP-3)轴关联的最新研究进展。甲状腺激素敏感性异常通过影响生长激素-IGF-1轴功能参与矮小症的发病过程。新型生物标志物和评估指标的开发为临床提供了更精准的诊断工具，而表观遗传机制的深入研究为理解其分子机制提供了新视角。本综述旨在为矮小症的临床诊疗和科研方向提供参考。
Abstract: Short stature is a common disease in the field of pediatric endocrinology, and its pathogenesis involves abnormal functions of multiple endocrine axes. In recent years, the value of thyroid hormone sensitivity assessment in the diagnosis and treatment of short stature has attracted increasing attention. This article systematically reviews the latest research progress on thyroid hormone sensitivity assessment methods and their association with the insulin-like growth factor-1 (IGF-1)/insulin-like growth factor-binding protein-3 (IGFBP-3) axis. Abnormal thyroid hormone sensitivity participates in the pathogenesis of short stature by affecting the function of the growth hormone-IGF-1 axis. The development of new biomarkers and evaluation indicators provides more accurate diagnostic tools for clinical practice, while in-depth research on epigenetic mechanisms offers a new perspective for understanding its molecular mechanisms. This review aims to provide references for the clinical diagnosis, treatment, and research directions of short stature.
文章引用：朱俊珂, 李萍. 矮小症儿童甲状腺激素敏感性评估及其与IGF-1/IGFBP-3轴关联的研究进展[J]. 临床个性化医学, 2026, 5(1): 202-208. https://doi.org/10.12677/jcpm.2026.51030

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