甘油三酯葡萄糖指数、胰岛素抵抗与肌肉减少症的研究进展
Research Progress of Triglyceride Glucose Index, Insulin Resistance and Sarcopenia
DOI: 10.12677/jcpm.2026.51034, PDF,    科研立项经费支持
作者: 阎玮洋, 朱苗苗：济宁医学院临床医学院(附属医院)，山东 济宁；李 含, 王白菊, 刘 雷*：济宁医学院附属医院全科医学科，山东 济宁
关键词: 甘油三酯葡萄糖指数；胰岛素抵抗；肌肉减少症；综述；Triglyceride Glucose Index； Insulin Resistance； Sarcopenia； Summary
摘要: 肌肉减少症简称“肌少症”，是一种与年龄相关的进行性、全身性骨骼肌疾病，不仅与跌倒、失能、再住院及死亡等不良事件密切相关，而且严重影响患者的生活质量和健康状况。研究发现，胰岛素抵抗(Insulin resistance, IR)作为肌少症的重要发病机制之一，通过多种途径参与肌少症的发生发展。大量研究证明，甘油三酯–葡萄糖指数(Triglyceride-glucose index，TyG指数)作为IR替代生物标记物，因其简单、经济、有效，同时可作为预测肌少症的潜在生物标记物。该文对TyG指数、胰岛素抵抗与肌少症相关性的研究进展作一综述。
Abstract: Sarcopenia is a progressive and systemic skeletal muscle disease associated with age. It is not only closely related to adverse events, such as falls, disability, rehospitalization and death, but also seriously affects the quality of life and health of patients. Studies have found that insulin resistance (IR), as one of the important pathogeneses of sarcopenia, is involved in the occurrence and development of sarcopenia through a variety of ways. A large number of studies have shown that the triglyceride-glucose index (TyG index), as an alternative biomarker for IR, is simple, economical and effective, and can be used as a potential biomarker for predicting sarcopenia. This article reviews the research progress of the correlation between TyG index, insulin resistance and sarcopenia.
文章引用：阎玮洋, 朱苗苗, 李含, 王白菊, 刘雷. 甘油三酯葡萄糖指数、胰岛素抵抗与肌肉减少症的研究进展[J]. 临床个性化医学, 2026, 5(1): 231-240. https://doi.org/10.12677/jcpm.2026.51034

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