维生素D与类风湿关节炎的相关性研究进展
Research Progress on the Relationship between Vitamin D and Rheumatoid Arthritis
DOI: 10.12677/jcpm.2026.51044, PDF,   
作者: 甘秋艳：右江民族医学院研究生院，广西 百色；陶丽菊*：右江民族医学院附属医院风湿免疫科，广西 百色
关键词: 类风湿关节炎；维生素D；骨质疏松；Rheumatoid Arthritis； Vitamin D； Osteoporosis
摘要: 类风湿关节炎(rheumatoid arthritis, RA)是一种慢性自身免疫性疾病，以侵蚀性、对称性多关节炎为主要临床表现，随着病情的进展逐渐出现关节软骨和骨的破坏，最终导致关节畸形和功能丧失。维生素D除具有干预钙和磷酸盐代谢及骨稳态作用外，还具有抑制促炎细胞因子的产生、抗纤维化、抗氧化及免疫调节的作用；如维生素D缺乏可促使促炎细胞因子的产生而加剧炎症反应，另外维生素D缺乏还可通过破骨细胞的活化导致骨质流失。治疗上维生素D治疗可以明显改善RA患者的症状。本文对维生素D与RA关系的研究现状进行综述，以期为临床医生在RA的诊治研究中提供参考。
Abstract: Rheumatoid arthritis (RA) is a chronic autoimmune disease with erosive and symmetrical polyarthritis as the main clinical manifestations. With the progression of the disease, the destruction of articular cartilage and bone gradually occurs, eventually leading to joint deformity and loss of function. In addition to interfering with calcium and phosphate metabolism and bone homeostasis, vitamin D also has the effects of inhibiting the production of pro-inflammatory cytokines, anti-fibrosis, anti-oxidation and immune regulation. For example, vitamin D deficiency can promote the production of pro-inflammatory cytokines and aggravate the inflammatory response. In addition, vitamin D deficiency can also lead to bone loss through osteoclast activation. Vitamin D treatment can significantly improve the symptoms of RA patients. This article reviews the research status of the relationship between vitamin D and RA, in order to provide a reference for clinicians in the diagnosis and treatment of RA.
文章引用：甘秋艳, 陶丽菊. 维生素D与类风湿关节炎的相关性研究进展[J]. 临床个性化医学, 2026, 5(1): 305-311. https://doi.org/10.12677/jcpm.2026.51044

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