经动脉介入灌注化疗治疗全身化疗不耐受的晚期非小细胞肺癌1例

Transarterial Chemotherapy Infusion for Advanced Non-Small Cell Lung Cancer in a Patient Intolerant to Systemic Chemotherapy: A Case Report

摘要: 对于不可手术切除且对全身静脉化疗不耐受的晚期非小细胞肺癌患者，治疗选择有限，预后通常较差。本文报道一例63岁男性患者，诊断为不可手术切除的晚期非小细胞肺癌，因无法耐受全身静脉化疗，自行口服中草药、中断免疫治疗后出现疾病进展，并伴有严重阻塞性肺炎。该患者在接受经动脉介入灌注化疗后，取得了显著的临床和影像学改善。旨在为此类难治性患者提供一种有效的局部治疗选择，为临床治疗策略提供了有价值的参考。

Abstract: Patients with advanced non-small cell lung cancer (NSCLC) who are ineligible for surgical resection and intolerant to systemic intravenous chemotherapy have limited treatment options and generally a poor prognosis. This paper reports the case of a 63-year-old male diagnosed with unresectable advanced NSCLC. After disease progression following self-administered oral Chinese herbal medicine due to intolerance to systemic intravenous chemotherapy, the patient developed severe obstructive pneumonia. Following treatment with transarterial interventional chemotherapy infusion, significant clinical and radiographic improvement was achieved. This case aims to provide an effective local treatment option for such refractory patients and offers a valuable reference for clinical treatment strategies.