影像组学:开启乳腺癌淋巴结转移术前评估的新视野
Imaging: A New Vision for Preoperative Evaluation of Lymph Node Metastasis in Breast Cancer
DOI: 10.12677/acm.2026.161016, PDF,   
作者: 邹妍娜, 赵 玲, 李慕贞, 姜霁洋, 陈伟彬*:华北理工大学附属医院医学影像中心,河北 唐山
关键词: 乳腺癌影像组学腋窝淋巴结转移Breast Cancer Imaging Axillary Lymph Node Metastasis
摘要: 乳腺癌是全球女性高发恶性肿瘤,腋窝淋巴结转移状态直接关联患者预后评估与个体化治疗方案制定,其术前精准评估对改善患者生存质量至关重要。传统超声、X线、MRI等影像学检查依赖医师主观经验判断,对微小或隐匿性转移灶诊断准确性有限,易导致误诊漏诊。影像组学通过高通量提取影像定量特征,结合机器学习、深度学习算法构建预测模型,可客观量化肿瘤生物学特征,显著提升淋巴结转移评估精准度。本文综述超声、X线、MRI影像组学在乳腺癌术前淋巴结转移评估中的研究进展,分析各模态技术优势与应用局限,为影像组学技术临床转化及优化乳腺癌诊疗策略提供参考。
Abstract: Breast cancer is a high-incidence malignant tumor among women all over the world. Axillary lymph node metastasis is directly related to the prognosis evaluation and individualized treatment plan, and its accurate preoperative evaluation is very important to improve the quality of life of patients. Traditional imaging examinations, such as ultrasound, X-ray and MRI, rely on doctors’ subjective experience and judgment, and the accuracy of diagnosis for tiny or occult metastases is limited, which easily leads to misdiagnosis and missed diagnosis. Imaging genomics can extract the quantitative features of images by Qualcomm, and build a prediction model by combining machine learning and deep learning algorithms, which can objectively quantify the biological features of tumors and significantly improve the accuracy of lymph node metastasis assessment. This paper reviews the research progress of ultrasound, X-ray and MRI imaging in preoperative lymph node metastasis assessment of breast cancer, analyzes the advantages and application limitations of each modality technology, and provides reference for clinical transformation of imaging technology and optimization of breast cancer diagnosis and treatment strategy.
文章引用:邹妍娜, 赵玲, 李慕贞, 姜霁洋, 陈伟彬. 影像组学:开启乳腺癌淋巴结转移术前评估的新视野[J]. 临床医学进展, 2026, 16(1): 112-118. https://doi.org/10.12677/acm.2026.161016

参考文献

[1] Breast Cancer Committee and China Anti-Cancer Association (2025) [Chinese Clinical Practice Guideline for Genetic Testing in Advanced Breast Cancer (2025 Edition)]. Chinese Journal of Oncology, 47, 946-960.
[2] Bray, F., Laversanne, M., Sung, H., Ferlay, J., Siegel, R.L., Soerjomataram, I., et al. (2024) Global Cancer Statistics 2022: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries. CA: A Cancer Journal for Clinicians, 74, 229-263. [Google Scholar] [CrossRef] [PubMed]
[3] Wang, X., Xia, C., Wang, Y., Qi, Y., Qi, X., Zhao, J., et al. (2023) Landscape of Young Breast Cancer under 35 Years in China over the Past Decades: A Multicentre Retrospective Cohort Study (YBCC-Catts Study). eClinicalMedicine, 64, Article ID: 102243. [Google Scholar] [CrossRef] [PubMed]
[4] Bai, G., Zhong, X., Wu, Y., Lin, W., Zhou, S. and Zhou, P. (2025) Predicting Axillary Lymph Node Metastasis in Breast Cancer Using Ultrasound and Machine Learning with SHAP. Cancer Management and Research, 17, 2183-2197. [Google Scholar] [CrossRef
[5] Lambin, P., Rios-Velazquez, E., Leijenaar, R., Carvalho, S., van Stiphout, R.G.P.M., Granton, P., et al. (2012) Radiomics: Extracting More Information from Medical Images Using Advanced Feature Analysis. European Journal of Cancer, 48, 441-446. [Google Scholar] [CrossRef] [PubMed]
[6] 赵楠楠, 朱芸, 汤晓敏, 等. 基于瘤内及瘤周MRI影像组学列线图预测乳腺癌腋窝淋巴结转移[J]. 磁共振成像, 2023, 14(3): 81-87, 94.
[7] 王贇霞, 尚怡研, 郭亚欣, 等. DCE-MRI影像组学特征在预测乳腺癌腋窝淋巴结转移中的价值[J]. 磁共振成像, 2023, 14(3): 21-27.
[8] 汪媛媛, 余建群. 乳腺癌腋窝淋巴结转移的影像及影像组学研究进展[J]. 放射学实践, 2023, 38(5): 662-666.
[9] Wei, M., Du, Y., Wu, X., Su, Q., Zhu, J., Zheng, L., et al. (2020) A Benign and Malignant Breast Tumor Classification Method via Efficiently Combining Texture and Morphological Features on Ultrasound Images. Computational and Mathematical Methods in Medicine, 2020, Article ID: 5894010. [Google Scholar] [CrossRef] [PubMed]
[10] Sha, Y., Ge, S., Wang, Y., Cai, S., Wang, C., Zhuang, H., et al. (2025) Ultrasound-Based Radiomics Combined with B3GALT4 Level to Predict Sentinel Lymph Node Metastasis in Primary Breast Cancer. Frontiers in Oncology, 15, Article 1570493. [Google Scholar] [CrossRef] [PubMed]
[11] 魏伟, 冯慧俊, 王晔, 等. 基于超声影像组学列线图预测T1期乳腺癌同侧腋窝淋巴结转移的价值[J]. 中国医学影像学杂志, 2024, 32(8): 796-802, 808.
[12] Wang, Z., Zhang, H., Lin, F., Zhang, R., Ma, H., Shi, Y., et al. (2023) Intra-and Peritumoral Radiomics of Contrast-Enhanced Mammography Predicts Axillary Lymph Node Metastasis in Patients with Breast Cancer: A Multicenter Study. Academic Radiology, 30, S133-S142. [Google Scholar] [CrossRef] [PubMed]
[13] 杜瑶, 吴萌, 王玉华, 等. 基于乳腺癌原发灶瘤内及瘤周超声影像组学特征预测腋窝淋巴结转移[J]. 中国医学影像学杂志, 2025, 33(10): 1056-1062.
[14] Liu, X., Li, J., He, Y., et al. (2024) Correlation between SWE Parameters and Histopathological Features and Immunohistochemical Biomarkers in Invasive Breast Cancer. Journal of Central South University. Medical Sciences, 49, 1941-1952.
[15] 乔江华, 朱立元, 韦伟. 数字化钼靶检查在判断乳腺癌腋窝淋巴结转移中的价值探讨[J]. 临床外科杂志, 2007(11): 751-752.
[16] 谢玉海, 马培旗, 王小雷, 等. 基于数字化乳腺X线影像组学预测浸润性乳腺癌腋窝淋巴结转移的多中心研究[J]. 放射学实践, 2024, 39(1): 31-36.
[17] Liu, X., Ruan, Y., Cao, S., Zhao, M., Shi, Z., Jin, Y., et al. (2025) Development and Internal Validation of a Mammography-Based Model Fusing Clinical, Radiomics, and Deep Learning Models for Sentinel Lymph Node Metastasis Prediction in Breast Cancer. Frontiers in Medicine, 12, Article 1659422. [Google Scholar] [CrossRef
[18] Han, Y., Huang, M., Xie, L., Cao, Y. and Dong, Y. (2025) The Value of Intratumoral and Peritumoral Radiomics Features Based on Multiparametric MRI for Predicting Molecular Staging of Breast Cancer. Frontiers in Oncology, 15, Article 1379048. [Google Scholar] [CrossRef] [PubMed]
[19] Zhang, J., Zhang, Z., Mao, N., Zhang, H., Gao, J., Wang, B., et al. (2023) Radiomics Nomogram for Predicting Axillary Lymph Node Metastasis in Breast Cancer Based on DCE-MRI: A Multicenter Study. Journal of X-Ray Science and Technology: Clinical Applications of Diagnosis and Therapeutics, 31, 247-263. [Google Scholar] [CrossRef] [PubMed]
[20] Dong, X., Meng, J., Xing, J., Jia, S., Li, X. and Wu, S. (2025) Predicting Axillary Lymph Node Metastasis in Young Onset Breast Cancer: A Clinical-Radiomics Nomogram Based on DCE-MRI. Breast Cancer: Targets and Therapy, 17, 103-113. [Google Scholar] [CrossRef] [PubMed]
[21] Wu, P., Guo, F., Wang, J., Gao, Y., Feng, S., Chen, S., et al. (2024) Development and Validation of a Dynamic Contrast-Enhanced Magnetic Resonance Imaging-Based Habitat and Peritumoral Radiomic Model to Predict Axillary Lymph Node Metastasis in Patients with Breast Cancer: A Retrospective Study. Quantitative Imaging in Medicine and Surgery, 14, 8211-8226. [Google Scholar] [CrossRef] [PubMed]
[22] Chen, Y., Wang, L., Dong, X., Luo, R., Ge, Y., Liu, H., et al. (2023) Deep Learning Radiomics of Preoperative Breast MRI for Prediction of Axillary Lymph Node Metastasis in Breast Cancer. Journal of Digital Imaging, 36, 1323-1331. [Google Scholar] [CrossRef] [PubMed]
[23] 张舒妮, 赵楠楠, 李阳, 等. 多模态影像组学列线图术前预测乳腺浸润性导管癌腋窝淋巴结转移的价值[J]. 磁共振成像, 2024, 15(4): 78-87.
[24] 王文娟, 王倩倩, 郑琪, 等. 基于超声和DCE-MRI的双模态影像组学模型预测乳腺癌腋窝淋巴结转移负荷[J]. 中国超声医学杂志, 2025, 41(10): 1103-1107.
[25] Guo, F., Sun, S., Deng, X., Wang, Y., Yao, W., Yue, P., et al. (2024) Predicting Axillary Lymph Node Metastasis in Breast Cancer Using a Multimodal Radiomics and Deep Learning Model. Frontiers in Immunology, 15, Article 1482020. [Google Scholar] [CrossRef] [PubMed]