五子衍宗丸对尿酸性肾病的保护作用机制研究
Study on the Mechanism of Protective Effect of Wuzi Yanzong Pill on Uric Acid Nephropathy
DOI: 10.12677/tcm.2026.151008, PDF,    科研立项经费支持
作者: 李浩经, 赵卉卉, 颉彦鹏, 蔡萧君*：黑龙江省中医药科学院内分泌科，黑龙江 哈尔滨；李森渊：山西医科大学基础医学院，山西 太原；曾 琼：江苏省军区徐州第五离职干部休养所，江苏 徐州；郑应康：黑龙江中医药大学第一临床医学院，黑龙江 哈尔滨
关键词: 五子衍宗丸；尿酸性肾病；作用机制；Wuzi Yanzong Pill； Uric Acid Nephropathy； Mechanism of Action
摘要: 伴随着经济的飞速增长和高嘌呤饮食的增加，高尿酸血症的发病率逐年攀升，由此引发的尿酸性肾病的发病率也显著增加，并呈现出年轻化的趋势。历代医家及现代大多医家将尿酸性肾病发病的病理核心归为肾气亏虚。五子衍宗丸是补肾益精的经典名方，特别在男性生殖系统疾病的诊疗中占据重要地位，其在慢性肾病治疗体系中的应用也被研究者逐渐重视，并在干预尿酸性肾病上表现出巨大的潜力。本文综述了五子衍宗丸复方及单药可通过稳定尿酸稳态、抑制炎症、抗氧化应激、调节肠道菌群等途径改善尿酸性肾病，总结了五子衍宗丸对尿酸性肾病的保护作用机制，以期为五子衍宗丸干预尿酸性肾病的基础研究、临床应用提供参考。
Abstract: Accompanied by the rapid economic growth and the increase of high purine diet, the incidence of hyperuricemia is rising year by year, and the incidence of uric acid nephropathy caused by it is also increasing significantly and showing a trend of rejuvenation. The pathologic core of the onset of uric acid nephropathy has been categorized as deficiency of kidney qi by successive medical practitioners and most modern medical practitioners. Wuzi Yanzong Pill is a classic formula for tonifying the kidneys and benefiting the vital essence, especially in the diagnosis and treatment of male reproductive system diseases. Its application in the treatment system of chronic kidney disease has also been gradually emphasized by researchers and has shown great potential in intervening in uric acid nephropathy. In this paper, we reviewed that Wuzi Yanzong Pill ompound and single drug can improve uric acid nephropathy by stabilizing uric acid homeostasis, inhibiting inflammation, anti-oxidative stress, and regulating intestinal flora, and summarized the mechanism of protective effect of Wuzi Yanzong Pill on uric acid nephropathy, with a view to providing reference for the basic research and clinical application of Wuzi Yanzong Pill to intervene in uric acid nephropathy.
文章引用：李浩经, 李森渊, 赵卉卉, 曾琼, 颉彦鹏, 郑应康, 蔡萧君. 五子衍宗丸对尿酸性肾病的保护作用机制研究[J]. 中医学, 2026, 15(1): 51-57. https://doi.org/10.12677/tcm.2026.151008

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