VPS72在肝细胞癌中的预后意义及其与免疫浸润的相关性的生物信息学分析
Bioinformatics Analysis of the Prognostic Significance of VPS72 and Correlations with Immune Infiltrates in Hepatocellular Carcinoma
DOI: 10.12677/acrem.2026.141004, PDF,   
作者: 陈 琼, 王聪聪, 杨 鹏*：安徽医科大学第一附属医院输血科，安徽 合肥；张楠楠：深圳市第二人民医院检验科，广东 深圳
关键词: VPS72；肝细胞癌；生物信息学；预后价值；VPS72； LIHC； Bioinformatics； Prognostic Values
摘要: 背景：VPS72是EP400和Snf2相关的CBP激活蛋白(SRCAP)染色质重塑复合物的组成部分。目前，VPS72在肝细胞癌(Hepatocellular Carcinoma, LIHC)中的预后价值尚不明确。方法：本研究利用ONCOMINE、UALCAN、GEPIA、STRING和TIMER等多个公共数据库，系统分析了VPS72在肝细胞癌中的表达特征及其临床意义。结果：分析后发现，在肝细胞癌(LIHC)中，VPS72的过表达与临床分期和病理分级显著相关，且其mRNA高表达与患者总生存期缩短密切相关。此外，VPS72启动子区在肝癌中存在明显的高甲基化改变。进一步分析显示，VPS72的表达与LIHC中B细胞、CD4⁺ T细胞、CD8⁺ T细胞、巨噬细胞、中性粒细胞和树突状细胞的浸润水平呈显著正相关。最后通过STRING数据库还构建了VPS72的蛋白质相互作用网络。结论：VPS72可能作为LIHC患者预后判断和免疫治疗靶点的潜在生物标志物。
Abstract: Background: VPS72 forms part of the EP400 and Snf2-related CBP-activator protein (SRCAP) chromatin remodeling complexes. The prognostic value of VPS72 in hepatocellular carcinoma is not known. Methods: We used the ONCOMINE, UALCAN, GEPIA, STRING and TIMER databases to study the expression of VPS72 in hepatocellular carcinoma and its medical significance. Results: Analysis revealed that VPS72 overexpression was markedly correlated with both clinical stage and pathological grade in Liver hepatocellular carcinoma (LIHC), and that higher mRNA expression of VPS72 was significantly related to shorter overall survival. Moreover, we observed significant differences in the hypermethylation of the VPS72 promoter in liver cancer. Furthermore, we identified significant correlations between the expression of VPS72 and the infiltration of B cells, CD4+ T cells, CD8+ T cells, macrophages, neutrophils, and dendritic cells in LIHC. Finally, a protein interaction network for VPS72 was constructed using the STRING database. Conclusion: VPS72 may be useful as a prognostic biomarker and immunotherapeutic target in LIHC patients.
文章引用：陈琼, 王聪聪, 张楠楠, 杨鹏. VPS72在肝细胞癌中的预后意义及其与免疫浸润的相关性的生物信息学分析[J]. 亚洲急诊医学病例研究, 2026, 14(1): 28-36. https://doi.org/10.12677/acrem.2026.141004

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