三叉神经痛与睡眠障碍的双向关系：病理生理机制及临床管理策略
The Bidirectional Relationship between Trigeminal Neuralgia and Sleep Disturbances: Pathophysiological Mechanisms and Clinical Management Strategies
DOI: 10.12677/acm.2026.161100, PDF,    科研立项经费支持
作者: 刘妍辰, 袁 勇, 唐一平*：昆明医科大学第二附属医院神经外科，云南 昆明；许建兴：开远市人民医院神经外科，云南 开远
关键词: 三叉神经痛；睡眠障碍；铁死亡；神经脱髓鞘；疼痛管理；Trigeminal Neuralgia； Sleep Disorders； Ferroptosis； Demyelination； Pain Management
摘要: 三叉神经痛(Trigeminal Neuralgia, TN)作为一种独特的慢性神经性疼痛疾病，与睡眠障碍之间存在复杂的双向关系。本文通过梳理疼痛的基本病理生理学机制、三叉神经痛的独特病理生理特征以及睡眠障碍的精神病学基础，深入探讨了疼痛与睡眠之间的关系。基于铁死亡理论和动物实验证据，结合临床观察数据，本文分析了三叉神经痛继发性睡眠障碍和原发性睡眠障碍引起疼痛复发的机制，并提出了针对性的临床管理建议，特别关注药物间的相互作用。
Abstract: Trigeminal neuralgia (TN), a distinct chronic neuropathic pain disorder, demonstrates a complex bidirectional association with sleep disturbances. This review synthesizes the fundamental pathophysiological mechanisms of pain, the unique neurobiological features of TN, and the psychiatric underpinnings of sleep disorders, thereby elucidating the intricate interplay between pain and sleep. Integrating ferroptosis theory and evidence from animal studies with clinical observational data, the analysis highlights the mechanisms underlying TN-related secondary sleep disturbances as well as the role of primary sleep disorders in precipitating pain recurrence. Based on these insights, targeted clinical management strategies are proposed, with particular attention to potential pharmacological interactions.
文章引用：刘妍辰, 许建兴, 袁勇, 唐一平. 三叉神经痛与睡眠障碍的双向关系：病理生理机制及临床管理策略[J]. 临床医学进展, 2026, 16(1): 752-759. https://doi.org/10.12677/acm.2026.161100

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