子宫非典型息肉样腺肌瘤1例并文献复习
Atypical Polypoid Adenomyoma of the Uterus: A Case Report and Literature Review
DOI: 10.12677/acm.2026.161104, PDF,   
作者: 褚慧婷, 霍靖雯:青岛大学青岛医学院,山东 青岛;蒋长青, 韩 毅, 王 宁*:青岛大学附属医院妇科,山东 青岛
关键词: 子宫非典型息肉样腺肌瘤临床病理宫腔镜手术治疗随访Atypical Polypoid Adenomyoma Clinicopathology Hysteroscopic Surgery Treatment Follow-Up
摘要: 非典型息肉样腺肌瘤(atypical polypoid adenomyoma, APA)是一种非常罕见的息肉样子宫肿瘤,由非典型子宫内膜腺体细胞和平滑肌间质成分组成,虽然为良性病变,但有进展成子宫内膜恶性肿瘤的风险,常合并子宫内膜癌或子宫内膜非典型增生。发病机制不详,临床多表现为异常子宫出血及不孕等,超声诊断难以与子宫内膜息肉及粘膜下肌瘤鉴别,主要依靠术后病理诊断,针对患者的年龄、生育要求及术后病理诊断,有不同的治理方案。根据现报道1例有生育要求的APA患者,通过系统性回顾相关文献,学习该病的主要诊疗方式。
Abstract: Atypical polypoid adenomyoma is a very rare polypoid uterine tumor composed of atypical endometrial glandular cells and smooth muscle stromal components. Although it is a benign lesion, it carries a risk of progression to endometrial malignancy and is often associated with endometrial carcinoma or endometrial atypical hyperplasia. The pathogenesis remains unclear. Clinically, it predominantly presents with abnormal uterine bleeding and infertility. Ultrasound examination is often insufficient to distinguish it from endometrial polyps or submucosal fibroids, and the diagnosis primarily relies on postoperative pathological examination. Treatment strategies vary based on the patient’s age, fertility desire, and postoperative pathological findings. Herein, we report a case of APA in a patient desiring fertility and summarize the main diagnostic and therapeutic approaches through a systematic review of the literature.
文章引用:褚慧婷, 霍靖雯, 蒋长青, 韩毅, 王宁. 子宫非典型息肉样腺肌瘤1例并文献复习[J]. 临床医学进展, 2026, 16(1): 784-789. https://doi.org/10.12677/acm.2026.161104

参考文献

[1] Raffone, A., Travaglino, A., Saccone, G., Alviggi, C., Mascolo, M., De Placido, G., et al. (2019) Management of Women with Atypical Polypoid Adenomyoma of the Uterus: A Quantitative Systematic Review. Acta Obstetricia et Gynecologica Scandinavica, 98, 842-855. [Google Scholar] [CrossRef] [PubMed]
[2] Mazur, M.T. (1981) Atypical Polypoid Adenomyomas of the Endometrium. The American Journal of Surgical Pathology, 5, 473-482. [Google Scholar] [CrossRef] [PubMed]
[3] Longacre, T.A., Chung, H., Rouse, R.V. and Hendrickson, M.R. (1996) Atypical Polypoid Adenomyofibromas (Atypical Polypoid Adenomyomas) of the Uterus: A Clinicopathologic Study of 55 Cases. The American Journal of Surgical Pathology, 20, 1-20. [Google Scholar] [CrossRef] [PubMed]
[4] 陈波, 朱兰, 郎景和. 子宫内膜非典型息肉样腺肌瘤的临床特点[J]. 中华医学杂志, 2012(15): 1049-1051.
[5] Jiang, Q., Wang, L. and Wu, R. (2013) A Multiple Perspectives on Atypical Polypoid Adenomyoma of Uterus. Gynecological Endocrinology, 29, 623-625. [Google Scholar] [CrossRef] [PubMed]
[6] Horn, L.C., Fischer, U. and Höckel, M. (2002) Polypoid Endometrial Adenomyoma in a Postmenopausal Woman, Mimicking Cervical Cancer, Associated with Ovarian Thecoma. Archives of Gynecology and Obstetrics, 267, 101-103. [Google Scholar] [CrossRef] [PubMed]
[7] 邹普润, 林彤, 周卫华. 1例绝经后子宫内膜非典型息肉样腺肌瘤[J]. 中国当代医药, 2022, 29(7): 147-150.
[8] 刘麒薇, 许阡, 孙馥箐, 等. 子宫内膜非典型息肉样腺肌瘤保守治疗方案的分析与评价[J]. 现代妇产科进展, 2025, 34(2): 135-138.
[9] Lu, B., Yu, M., Shi, H. and Chen, Q. (2019) Atypical Polypoid Adenomyoma of the Uterus: A Reappraisal of the Clinicopathological and Immunohistochemical Features. Pathology-Research and Practice, 215, 766-771. [Google Scholar] [CrossRef] [PubMed]
[10] 张楚霜. 多普勒彩超在鉴别子宫黏膜下肌瘤与非典型息肉样腺肌瘤中的价值[J]. 现代医用影像学, 2025, 34(4): 739-742+768.
[11] 王欣, 金佟, 郭银树. 子宫非典型息肉样腺肌瘤49例临床分析[J]. 中国微创外科杂志, 2020, 20(10): 887-890.
[12] 张丽娟, 段爱红, 盛洁. 子宫非典型息肉样腺肌瘤138例临床分析[J]. 中国微创外科杂志, 2016, 16(8): 681-684.
[13] 翟翠静, 张红凯. 11例子宫非典型息肉样腺肌瘤临床病理特征分析研究[J]. 诊断病理学杂志, 2025, 32(6): 629-634.
[14] 肖婉婷, 邹倩. 子宫非典型息肉样腺肌瘤研究进展[J]. 国际生殖健康/计划生育杂志, 2023, 42(6): 524-528.
[15] Worrell, H.I., Sciallis, A.P. and Skala, S.L. (2021) Patterns of SATB2 and P16 Reactivity Aid in the Distinction of Atypical Polypoid Adenomyoma from Myoinvasive Endometrioid Carcinoma and Benign Adenomyomatous Polyp on Endometrial Sampling. Histopathology, 79, 96-105. [Google Scholar] [CrossRef] [PubMed]
[16] Kihara, A., Amano, Y., Yoshimoto, T., 等. 间质p16表达有助于伴肌层浸润的子宫内膜样癌与非典型息肉样腺肌瘤的鉴别[J]. 临床与实验病理学杂志, 2020, 36(5): 556.
[17] Bui, C.M., Azimpouran, M., Balzer, B., Maluf, H. and Medeiros, F. (2024) Stromal P16 and SATB2 Expression Does Not Distinguish Atypical Polypoid Adenomyoma (APA) from Its Benign Mimics. International Journal of Gynecological Pathology, 43, 586-594. [Google Scholar] [CrossRef] [PubMed]
[18] Bai, T.J., Bao, D.M., Li, Y., et al. (2017) Atypical Polypoid Adenomyoma of the Uterus: A Clinicopathological Review of 27 Cases. Chinese Journal of Obstetrics and Gynecology, 52, 244-248.
[19] Mitranovici, M.I., Oală, I.E., Petre, I., Craina, M.L., Floruț, S.N., Chiorean, D.M., et al. (2022) Atypical Polypoid Adenomyoma of the Vagina: Follow up and Subsequent Evolution: A Case Report and Update. Diagnostics, 12, Article No. 368. [Google Scholar] [CrossRef] [PubMed]
[20] Chiyoda, T., Lin, B., Saotome, K., Kiyokawa, S. and Nakada, S. (2018) Hysteroscopic Transcervical Resection for Atypical Polypoid Adenomyoma of the Uterus: A Valid, Fertility-Preserving Option. Journal of Minimally Invasive Gynecology, 25, 163-169.e1. [Google Scholar] [CrossRef] [PubMed]
[21] Matoba, Y., Banno, K., Kobayashi, Y., Kisu, I. and Aoki, D. (2019) Atypical Polypoid Adenomyoma Treated by Hysteroscopy with Photodynamic Diagnosis Using 5-Aminolevulinic Acid: A Case Report. Photodiagnosis and Photodynamic Therapy, 27, 295-297. [Google Scholar] [CrossRef] [PubMed]
[22] Wong, A.Y.K., Chan, K., Lau, W. and Tang, L.C.H. (2007) Pregnancy Outcome of a Patient with Atypical Polypoid Adenomyoma. Fertility and Sterility, 88, 1438.e7-1438.e9. [Google Scholar] [CrossRef] [PubMed]
[23] 张丽娟, 段爱红, 盛洁. 宫腔镜联合孕激素治疗子宫非典型息肉样腺肌瘤的中远期疗效[J]. 中国微创外科杂志, 2018, 18(12): 1076-1079.
[24] Ferrazzi, E., Zupi, E., Leone, F.P., Savelli, L., Omodei, U., Moscarini, M., et al. (2009) How Often Are Endometrial Polyps Malignant in Asymptomatic Postmenopausal Women? A Multicenter Study. American Journal of Obstetrics and Gynecology, 200, 235.e1-235.e6. [Google Scholar] [CrossRef] [PubMed]
[25] Thanasa, E.I., Thanasa, A.I., Paraoulakis, I.E., et al. (2023) Surgical Treatment of a Rare Case of Atypical Polypoid Adenomyoma of the Uterus in a Menopausal Patient: A Case Report. Pan African Medical Journal, 44, Article No. 118.
[26] Nomura, H., Sugiyama, Y., Tanigawa, T., Matoda, M., Kanao, H., Kondo, E., et al. (2015) Long-Term Outcomes of Fertility-Sparing Treatment of Atypical Polypoid Adenomyoma with Medroxyprogesterone Acetate. Archives of Gynecology and Obstetrics, 293, 177-181. [Google Scholar] [CrossRef] [PubMed]