人体有机磷酸酯内暴露水平及相关健康风险的研究进展
Human Internal Exposure to Organophosphate Esters and Associated Health Risks: A Review
DOI: 10.12677/acm.2026.161111, PDF,   
作者: 刘玲菲：山东大学齐鲁医学院公共卫生学院职业与环境健康学系，山东 济南
关键词: 有机磷酸酯；人群暴露；生物监测；健康风险；环境流行病学；Organophosphate Esters； Human Exposure； Biomonitoring； Health Risks； Environmental Epidemiology
摘要: 有机磷酸酯(organophosphate esters, OPEs)作为新型阻燃剂与增塑剂，凭借其广泛的工业与商业应用，在全球环境中广泛分布。鉴于其易释放和持久存在的特性，OPEs已成为环境及人体中普遍检出的新兴污染物。现有研究显示，OPEs可通过吸入、摄入以及皮肤接触等多途径进入人体，已在尿液、血液、母乳、指甲及头发等多种生物基质中被检测到。此外，流行病学研究提示OPEs暴露与多种不良健康结局相关。因此，本文对不同地区、性别、年龄及职业人群的暴露水平展开综述，剖析人体内OPEs的暴露特征，旨在为系统评估OPEs的暴露风险以及制定环境防控与健康管理策略提供科学依据。
Abstract: Organophosphate esters (OPEs), widely used as novel flame retardants and plasticizers, have become globally distributed in the environment due to their extensive industrial and commercial applications. Owing to their tendency to leach and their persistence, OPEs have emerged as ubiquitous environmental contaminants detected in both environmental media and the human body. Current studies indicate that OPEs can enter the human body through multiple pathways, including inhalation, ingestion, and dermal absorption, and can be detected in various biological matrices such as urine, blood, breast milk, nails, and hair. Epidemiological evidence further suggests that OPE exposure is associated with multiple adverse health outcomes. This review summarizes the exposure levels of OPEs among populations of different regions, sexes, ages, and occupations, aiming to elucidate the characteristics of internal exposure and provide scientific evidence for comprehensive risk assessment, environmental control, and health management strategies regarding OPEs.
文章引用：刘玲菲. 人体有机磷酸酯内暴露水平及相关健康风险的研究进展[J]. 临床医学进展, 2026, 16(1): 835-842. https://doi.org/10.12677/acm.2026.161111

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