胃癌术后临床辅助治疗的研究进展

Research Progress in Clinical Adjuvant Therapy after Gastric Cancer Surgery

摘要: 胃癌术后辅助治疗是改善患者预后的关键环节，近年来已从传统化疗发展为包含免疫治疗、靶向治疗及腹腔灌注化疗等的多元化方案。本文系统综述了腹腔常温灌注化疗、免疫检查点抑制剂及分子靶向药物等核心辅助方法的机制与应用进展，分析了当前个体化治疗决策依据不足的问题，并提出构建更全面的多组学与动态监测技术。通过整合生物标志物、ctDNA监测及人工智能决策支持，有望实现真正意义上的个体化治疗，提升疗效并改善患者生存质量。

Abstract: Adjuvant therapy after gastric cancer surgery is a key step in improving patient prognosis and has developed in recent years from traditional chemotherapy to diversified approaches including immunotherapy, targeted therapy, and intraperitoneal chemotherapy. This article systematically reviews the mechanisms and application progress of core adjuvant methods such as normothermic intraperitoneal chemotherapy, immune checkpoint inhibitors, and molecular targeted drugs, analyzes the current lack of evidence for individualized treatment decisions, and proposes the development of more comprehensive multi-omics and dynamic monitoring technologies. By integrating biomarkers, ctDNA monitoring, and artificial intelligence decision support, it is hoped that truly personalized treatment can be achieved, improving therapeutic efficacy and patient quality of life.