锌补充在多囊卵巢综合征治疗中的作用：机制与临床证据
The Role of Zinc Supplementation in the Treatment of Polycystic Ovary Syndrome: Mechanisms and Clinical Evidence
DOI: 10.12677/acm.2026.161164, PDF,   
作者: 吕迎春：黑龙江中医药大学研究生院，黑龙江 哈尔滨；匡洪影*：黑龙江中医药大学附属第一医院妇科二科，黑龙江 哈尔滨
关键词: 多囊卵巢综合征；锌；锌补充；胰岛素抵抗；Polycystic Ovary Syndrome； Zinc； Zinc Supplementation； Insulin Resistance
摘要: 多囊卵巢综合征(polycystic ovary syndrome, PCOS)是常见的一种内分泌代谢紊乱疾病，临床表现高度异质性，以雄激素过量、排卵功能障碍和卵巢多囊样改变为主要特征。近年来，锌稳态在PCOS病理生理过程中的作用日益受到关注。本文系统综述了锌在PCOS卵泡发育、胰岛素抵抗、氧化应激和雄激素过量中的核心作用机制，评估了锌补充在改善PCOS代谢异常、内分泌紊乱和生殖功能障碍中的治疗潜力，并探讨了未来研究方向及临床转化面临的挑战。现有证据表明，锌稳态失衡是PCOS病理生理过程中的一个重要环节，而补锌可能成为改善PCOS症状的潜在治疗策略，为开发基于锌稳态调节的PCOS精准防治提供了新思路。
Abstract: Polycystic ovary syndrome (PCOS) is a common endocrine metabolic disorder characterized by high clinical heterogeneity, primarily manifested as hyperandrogenism, ovulatory dysfunction, and polycystic ovarian changes. In recent years, the role of zinc homeostasis in the pathophysiological processes of PCOS has garnered increasing attention. This systematic review examines zinc’s core mechanisms in PCOS follicular development, insulin resistance, oxidative stress, and hyperandrogenism. It evaluates zinc supplementation’s therapeutic potential for improving PCOS metabolic abnormalities, endocrine dysfunction, and reproductive disorders, while exploring future research directions and challenges in clinical translation. Existing evidence indicates that zinc homeostasis imbalance is a critical component in the pathophysiological process of PCOS, and zinc supplementation may emerge as a potential therapeutic strategy for alleviating PCOS symptoms. This provides new insights for developing precision prevention and treatment strategies for PCOS based on zinc homeostasis regulation.
文章引用：吕迎春, 匡洪影. 锌补充在多囊卵巢综合征治疗中的作用：机制与临床证据[J]. 临床医学进展, 2026, 16(1): 1267-1276. https://doi.org/10.12677/acm.2026.161164

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