基于激素补充治疗“关键期”假说探讨中医药改善围绝经期女性轻度认知障碍的优势

The Advantages of TCM in Improving MCI in Perimenopause Women Were Discussed Based on the Hypothesis of the “Critical Period” of Hormone Replacement Therapy

摘要: 围绝经期女性的认知功能衰退在临床上日益受到重视，目前国内外动物研究及临床研究均表明围绝经期雌激素水平的下降与神经退行性病变有着密切联系。雌激素补充疗法具有神经保护作用，有助于降低老年女性认知功能障碍的发生风险。而雌激素对于神经的保护作用存在一个重要时间段，若错过这一时间段进行治疗，可能会对患者产生不利影响。大多女性对激素补充治疗存在诸多顾虑，而中医药疗法在临床上具有广大的受众群体，同时临床研究表明中草药也具有类雌激素作用。临床上将中医药和激素补充有效结合有望成为新时代疗法，能为广大妇女带来更长远的临床疗效。

Abstract: Cognitive decline in perimenopause women has been paid more and more attention in clinical practice, and animal studies and clinical studies at home and abroad have shown that the decline of estrogen levels is closely related to neurodegeneration, and estrogen supplementation therapy has neuroprotective effects, which is beneficial to reduce the risk of cognitive dysfunction in older women. And there is an important period of time for estrogen to protect nerves, missing the critical time will have an adverse effect on the treatment of patients. The majority of women have many concerns about hormone replacement therapy, while TCM therapy has a wider audience, and clinical studies have shown that herbal medicine also has an estrogen-like effect. The effective combination of TCM and hormone supplementation is expected to become a new era of therapy, which can bring more long-term clinical effects to the majority of women.