小型啮齿类动物麻醉期无创生理监测系统设计及实现

Design and Implementation of a Non-Invasive Physiological Monitoring System for Small Rodents during Anesthesia

摘要: 为解决小型啮齿类动物在麻醉实验中多生理参数同步监测所面临的操作繁琐、设备集成度低、有创采集及缺乏体温维持等问题，本研究旨在研制一套无创生理监测系统，以实现心电、血氧及肛温信号的实时同步采集。系统采用四肢接触式电极设计，适配动物麻醉体位采集心电信号；使用集成温控底板以维持实验期间体温稳定；血氧监测通过小型化传感器及针对不同部位设计的专用探头实现；肛温则由热敏电阻通过直肠测温完成。该系统可在不影响实验操作的前提下，为麻醉状态下的小型啮齿类动物提供实时的多参数生理数据流。本系统集成度高、操作便捷，能为药理学、生理学及外科手术等领域的动物实验提供可靠的术中生命体征监测方案。

Abstract: To address the problems encountered in the synchronous monitoring of multiple physiological parameters of small rodents in anesthesia experiments, such as cumbersome operation, low equipment integration, invasive data collection, and lack of body temperature maintenance, this study aims to develop a non-invasive physiological monitoring system to realize real-time synchronous acquisition of electrocardiogram (ECG), blood oxygen, and rectal temperature signals. The system adopts a limb-contact electrode design, which is adapted to the anesthetic position of animals for ECG signal acquisition; an integrated temperature-controlled base plate is used to maintain stable body temperature during the experiment; blood oxygen monitoring is achieved through a miniaturized sensor and specialized probes designed for different body parts; rectal temperature is measured via a thermistor through rectal temperature detection. Without interfering with experimental operations, the system can provide real-time multi-parameter physiological data streams for small rodents under anesthesia. With high integration and easy operation, this system can provide a reliable intraoperative vital sign monitoring solution for animal experiments in fields such as pharmacology, physiology, and surgery.